ArticleJournal of molecular evolution2003
A novel strategy for analysis of gene homologues and segmental genome duplications.
Article in Journal of molecular evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- TAR Cloning: Perspectives for Functional Genomics, Biomedicine, and Biotechnology.Molecular therapy. Methods & clinical development · 2019Review
- Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.Chromosoma · 2016Review
- BrassicaTED - a public database for utilization of miniature transposable elements in Brassica species.BMC research notes · 2014Article
- Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeast.Genome research · 2004Article
- Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.PLoS biology · 2004Article
- A general cloning system to selectively isolate any eukaryotic or prokaryotic genomic region in yeast.BMC genomics · 2003Article
- Separation of long-range human TERT gene haplotypes by transformation-associated recombination cloning in yeast.Oncogene · 2003Article
- Optimum conditions for selective isolation of genes from complex genomes by transformation-associated recombination cloning.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Transformation-associated recombination (TAR) cloning allows selective isolation of a desired chromosomal region or gene from complex genomes. The method exploits a high level of recombination between homologous DNA sequences during transformation in the yeast Saccharomyces cerevisiae. We investigated the effect of nonhomology on the efficiency of gene capture and found that up to 15% DNA divergence did not prevent efficient gene isolation. Such tolerance to DNA divergence greatly expands the potential applications of TAR cloning for comparative genomics. In this study, we were able to use the technique to isolate nonidentical chromosomal duplications and gene homologues.
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Registered trials
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