ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2003
Long-term oral Candida colonization, mucositis and salivary function after head and neck radiotherapy.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010Pooled it
- Oral Fungal Infection Impacts Epithelial Innate Immunity to Promote Local and Distal Squamous Cell Carcinoma Progression.Cancer research · 2026Article
- Article
- Review
- Dimethylaminododecyl methacrylate inhibits Candida albicans and oropharyngeal candidiasis in a pH-dependent manner.Applied microbiology and biotechnology · 2020Article
- Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.International journal of molecular sciences · 2018Review
- Identification of uncommon oral yeasts from cancer patients by MALDI-TOF mass spectrometry.BMC infectious diseases · 2018Article
- Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection.Radiation research · 2016Article
- Prevalence of Candida albicans and Candida dubliniensis in caries-free and caries-active children in relation to the oral microbiota-a clinical study.Clinical oral investigations · 2016Article
- Evaluation of oral prophylaxis during and after intensity-modulated radiotherapy due to head and neck cancer--a retrospective study.Clinical oral investigations · 2016Article
- Xerostomia due to systemic disease: a review of 20 conditions and mechanisms.Annals of medical and health sciences research · 2014Review
- Evaluation of saliva flow rates, Candida colonization and susceptibility of Candida strains after head and neck radiation.Clinical oral investigations · 2012Article
- Drug induced xerostomia in elderly individuals: An institutional study.Contemporary clinical dentistry · 2012Article
- Efficacy of the BioXtra dry mouth care system in the treatment of radiotherapy-induced xerostomia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2007Article
- New thoughts on the pathobiology of regimen-related mucosal injury.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006Review
- Prospective study of the long term change of the oral flora after radiation therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006Article
- Radiation therapy and chemotherapy-induced oral mucositis.Brazilian journal of otorhinolaryngologyReview
- AnJournal of oral and maxillofacial pathology : JOMFPArticle
- Oral complications of radiotherapy in the head and neck.Brazilian journal of otorhinolaryngologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to follow the long-term effects of radiation therapy of head and neck malignancies on oral yeast colonization, mucositis and salivary function. Included in this prospective study were 32 patients with intended radiation therapy of a malignancy of the head and neck. In all patients the salivary glands lay within the radiation field and the patients had at least five teeth. The first examination was performed after oral hygiene instruction and removal of questionable teeth before the start of radiotherapy. The following examinations were conducted after 3, 6, 9 and 12 months. Together with the quantitative determination of Candida colonization, three "mucositis" variables were assessed: (1) examiner-rated mucositis score (LENT/SOMA), (2) patient-rated mucositis symptoms, and (3) scintigraphic salivary excretion fraction. The maximum Candida colonization was found 6 months after radiation therapy and this declined to above normal values after 12 months. Salivary flow was at a minimum 6 months after radiation therapy and had slightly recovered by 12 months. Examiner-rated mucositis and patient-rated xerostomia showed no significant recovery after 6 or 12 months. The results of this study show slight recovery of the oral ecological system. Although the causal role of a single parameter is not clear, persistently elevated Candida colonization should be taken into account therapeutically.
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Registered trials
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