ReviewOncogene2003
SV40 in human brain cancers and non-Hodgkin's lymphoma.
Review in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Antibodies reacting with Simian virus 40 mimotopes in serum samples from patients with thalassaemia major.Blood transfusion = Trasfusione del sangue · 2014Trial
- Review
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- Unusual cause of fever, vision loss and super refractory status epilepticus in association with simian virus 40 (SV40).BMJ case reports · 2018Article
- Survey for human polyomaviruses in cancer.JCI insight · 2016Article
- Birth weight and other perinatal factors and childhood CNS tumors: a case-control study in California.Cancer epidemiology · 2013Article
- Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case-Control Study (CEFALO).British journal of cancer · 2013Article
- Article
- Simian virus 40 transformation, malignant mesothelioma and brain tumors.Expert review of respiratory medicine · 2011Review
- Multi-faceted role of HSP40 in cancer.Clinical & experimental metastasis · 2009Review
- Simian virus 40 in humans.Infectious agents and cancer · 2007Article
- The cancer stem cell: evidence for its origin as an injured autoreactive T cell.Molecular cancer · 2006Review
- Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential.Journal of virology · 2005Article
- Immunodetection of SV40 large T antigen in human central nervous system tumours.Journal of clinical pathology · 2005Article
- Novel polyomavirus detected in the feces of a chimpanzee by nested broad-spectrum PCR.Journal of virology · 2005Article
- Municipal pleural cancer mortality in Spain.Occupational and environmental medicine · 2005Article
- Detection of human cytomegalovirus genome and gene products in central nervous system tumours.British journal of cancer · 2005Article
- Phylogenetic analysis of polyomavirus simian virus 40 from monkeys and humans reveals genetic variation.Journal of virology · 2004Article
- Emergent human pathogen simian virus 40 and its role in cancer.Clinical microbiology reviews · 2004Review
- Simian virus 40 and its association with human lymphomas.Current oncology reports · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Simian virus 40 (SV40) is a potent DNA tumor virus that is known to induce primary brain cancers and lymphomas in laboratory animals. SV40 oncogenesis is mediated by the viral large tumor antigen (T-ag), which inactivates the tumor-suppressor proteins p53 and pRb family members. During the last decade, independent studies using different molecular biology techniques have shown the presence of SV40 DNA, T-ag, or other viral markers in primary human brain cancers, and a systematic assessment of the data indicates that the virus is significantly associated with this group of human tumors. In addition, recent large independent studies showed that SV40 T-ag DNA is significantly associated with human non-Hodgkin's lymphoma (NHL). Although the prevalence of SV40 infections in humans is not known, numerous observations suggest that SV40 is a pathogen in the human population today. This review examines the molecular biology, pathology, and clinical data implicating SV40 in the pathogenesis of primary human brain cancers and NHL and discusses future research directions needed to define a possible etiologic role for SV40 in these malignancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.