ArticleProceedings of the National Academy of Sciences of the United States of America2003
High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 139 citations in OpenAlex.
- Unsupervised learning analysis on the proteomes of Zika virus.PeerJ. Computer science · 2024Article
- Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability.Nature communications · 2022Article
- Polygenic risk modeling of tumor stage and survival in bladder cancer.BioData mining · 2022Article
- Exploring Patient Multimorbidity and Complexity Using Health Insurance Claims Data: A Cluster Analysis Approach.JMIR medical informatics · 2022Article
- Article
- Differential Allelic Expression among Long Non-Coding RNAs.Non-coding RNA · 2021Review
- Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Oropharyngeal cancer patient stratification using random forest based-learning over high-dimensional radiomic features.Scientific reports · 2021Article
- X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as "Faux Amis".Frontiers in cell and developmental biology · 2021Review
- Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6.RNA (New York, N.Y.) · 2020Article
- New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation.Frontiers in cell and developmental biology · 2020Review
- Characterization of bovine (Bos taurus) imprinted genes from genomic to amino acid attributes by data mining approaches.PloS one · 2019Article
- L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing.The Journal of cell biology · 2018Article
- Conservation of Repeats at the Mammalian KCNQ1OT1-CDKN1C Region Suggests a Role in Genomic Imprinting.Evolutionary bioinformatics online · 2017Article
- Review
- Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.Genome research · 2015Article
- LINE-1 retrotransposons: from 'parasite' sequences to functional elements.Journal of applied genetics · 2015Article
- Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving theTranslational neuroscience · 2015Review
- ASAR15, A cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15.PLoS genetics · 2015Article
- Independent recruitment of Igh alleles in V(D)J recombination.Nature communications · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Genes subject to monoallelic expression are expressed from only one of the two alleles either selected at random (random monoallelic genes) or in a parent-of-origin specific manner (imprinted genes). Because high densities of long interspersed nuclear element (LINE)-1 transposon sequence have been implicated in X-inactivation, we asked whether monoallelically expressed autosomal genes are also flanked by high densities of LINE-1 sequence. A statistical analysis of repeat content in the regions surrounding monoallelically and biallelically expressed genes revealed that random monoallelic genes were flanked by significantly higher densities of LINE-1 sequence, evolutionarily more recent and less truncated LINE-1 elements, fewer CpG islands, and fewer base-pairs of short interspersed nuclear elements (SINEs) sequence than biallelically expressed genes. Random monoallelic and imprinted genes were pooled and subjected to a clustering analysis algorithm, which found two clusters on the basis of aforementioned sequence characteristics. Interestingly, these clusters did not follow the random monoallelic vs. imprinted classifications. We infer that chromosomal sequence context plays a role in monoallelic gene expression and may involve the recognition of long repeats or other features. The sequence characteristics that distinguished the high-LINE-1 category were used to identify more than 1,000 additional genes from the human and mouse genomes as candidate genes for monoallelic expression.
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