ReviewGene2003
Regulation of gene expression by stop codon recoding: selenocysteine.
Review in Gene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- The Role of rs713041 Glutathione Peroxidase 4 (International journal of molecular sciences · 2022Pooled it
- Selenoproteins: Minute yet vital players governing cellular fate.Genes & diseases · 2026Review
- A multi-omic approach reveals iron availability influences cell fate fidelity.npj metabolic health and disease · 2026Article
- Uniquome: Construction and decoding of a novel proteomic atlas that contains new peptide entities.Computational and structural biotechnology journal · 2025Article
- Human selenocysteine synthase, SEPSECS, has evolved to optimize binding of a tRNA-based substrate.Nucleic acids research · 2024Article
- Distinct Roles of SELENOF in Different Human Cancers.Biomolecules · 2023Review
- Selenium Metabolism and Selenoproteins in Prokaryotes: A Bioinformatics Perspective.Biomolecules · 2022Review
- The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene.Epigenetics · 2020Article
- Selenium Interactions with Algae: Chemical Processes at Biological Uptake Sites, Bioaccumulation, and Intracellular Metabolism.Plants (Basel, Switzerland) · 2020Review
- Epitranscriptomic systems regulate the translation of reactive oxygen species detoxifying and disease linked selenoproteins.Free radical biology & medicine · 2019Review
- Nanoselenium prevents eimeriosis-induced inflammation and regulates mucin gene expression in mice jejunum.International journal of nanomedicine · 2018Article
- Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles.Metabolic brain disease · 2017Article
- Inherited defects in thyroid hormone cell-membrane transport and metabolism.Best practice & research. Clinical endocrinology & metabolism · 2014Review
- The syndromes of reduced sensitivity to thyroid hormone.Biochimica et biophysica acta · 2013Review
- Nanoparticles of selenium as species with stronger physiological effects in sheep in comparison with sodium selenite.Biological trace element research · 2012Article
- Translation in giant viruses: a unique mixture of bacterial and eukaryotic termination schemes.PLoS genetics · 2012Article
- Specific antioxidant selenoproteins are induced in the heart during hypertrophy.Archives of biochemistry and biophysics · 2011Article
- Inherited defects of thyroid hormone metabolism.Annales d'endocrinologie · 2011Review
- The efficiency of selenocysteine incorporation is regulated by translation initiation factors.Journal of molecular biology · 2010Article
- The syndrome of inherited partial SBP2 deficiency in humans.Antioxidants & redox signaling · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The regulation of gene expression at the translational level not only allows for rapid changes in specific protein levels but also provides an opportunity to alter codon specificity. For the incorporation of selenocysteine (Sec) into protein, the UGA codon is transformed from one that signals translation termination to one specific for Sec. This review provides a look at Sec incorporation from the perspective of the individual steps involved in protein synthesis: initiation, elongation and termination. The roles of the factors known to be required for Sec incorporation are considered in the context of each step in translation including structural modeling of the differences between the standard elongation factor eEF1A and the Sec-specific counterpart, eEFSec.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.