Evidence map›Paper›PMID 12907886›Full record

ReviewCritical care medicine2003

Mechanisms of immune resolution.

Alfred Ayala, Chun-Shiang Chung, Patricia S Grutkoski, Grace Y Song

Abstract readReview
In one paragraph

Review in Critical care medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Cholesterol metabolism: a new molecular switch to control inflammation.Clinical science (London, England : 1979) · 2021
    Review
  11. Article
  12. Article
  13. DNA-Based Biomaterials for Immunoengineering.Advanced healthcare materials · 2019
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alfred AyalaDepartment of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, 02903, USA. AAYALA@LIFESPAN.org
Chun-Shiang Chung
Patricia S Grutkoski
Grace Y Song

Funding

DIFFERENTIAL EFFECTS OF SEPSIS ON MACROPHAGE FUNCTIONR01GM046354 · NIGMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI AYALA, ALFRED · 1999 to 2016
$4.5M
PROGRAMMED CELL DEATH: ROLE IN SEPTIC IMMUNE SUPPRESSIONR01GM053209 · NIGMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI AYALA, ALFRED · 1995 to 2013
$3.0M
NIGMS NIH HHS R01 GM046354NIGMS NIH HHS R01 GM053209NIGMS NIH HHS R01 GM-46354NIGMS NIH HHS R01 GM-53209
6 · The paper itself

Abstract

Initially after injury, the innate/proinflammatory and some aspects of the acquired immune response are up-regulated to maintain a defense against foreign pathogens, clear tissue debris present at the wound site, and orchestrate aspects of tissue remodeling, cell proliferation and angiogenic process, associated with the wound response. However, for proper wound healing to progress, this initial inflammatory response has to be regulated or shut down so as to allow for the reestablishment of matrix, recellularization, and tissue remodeling. Inability to properly resolve the extent of innate/acquired response at a site of injury can lead to poor wound healing, immune suppression, and recurrent infectious episodes. This review attempts to summarize information on regulatory mechanisms that are thought to be involved in controlling/resolving innate or acquired immune responses so as to provide a framework for use in thinking about the impact these processes and their manipulation may have on wound healing and its potential management.

Indexed as

Critical CareCritical IllnessAnimalsHumansImmunity, ActiveImmunity, CellularImmunity, InnateRegenerationSystemic Inflammatory Response SyndromeWound HealingWounds and Injuries

Identifiers

PMID12907886
PMCPMC2248698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.