ArticleNucleic acids research2003
The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Trypanosomes can initiate nuclear export co-transcriptionally.Nucleic acids research · 2019Article
- An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri.Genome biology and evolution · 2017Article
- An Overview ofFrontiers in microbiology · 2016Review
- Advancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping.Molecular and biochemical parasitology · 2015Article
- Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome.Nucleic acids research · 2015Article
- Article
- Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei.Nucleic acids research · 2009Article
- Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169.Journal of cell science · 2008Article
- Histone acetylation and methylation at sites initiating divergent polycistronic transcription in Trypanosoma cruzi.The Journal of biological chemistry · 2008Article
- Biogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated.PLoS biology · 2008Article
- Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map.Genome biology · 2008Article
- Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes.Eukaryotic cell · 2007Article
- Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii.Genome research · 2006Article
- Hemizygous subtelomeres of an African trypanosome chromosome may account for over 75% of chromosome length.Genome research · 2006Article
- Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.Eukaryotic cell · 2006Article
- Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites.Journal of molecular evolution · 2005Article
- The genome of the kinetoplastid parasite, Leishmania major.Science (New York, N.Y.) · 2005Article
- A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes.RNA (New York, N.Y.) · 2005Article
- Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor.Nucleic acids research · 2005Article
- Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.Genome research · 2005Article
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Authors and funding
40 authors at 1 institution in 1 country.
Funding
Abstract
The African trypanosome, Trypanosoma brucei, causes sleeping sickness in humans in sub-Saharan Africa. Here we report the sequence and analysis of the 1.1 Mb chromosome I, which encodes approximately 400 predicted genes organised into directional clusters, of which more than 100 are located in the largest cluster of 250 kb. A 160-kb region consists primarily of three gene families of unknown function, one of which contains a hotspot for retroelement insertion. We also identify five novel gene families. Indeed, almost 20% of predicted genes are members of families. In some cases, tandemly arrayed genes are 99-100% identical, suggesting an active process of amplification and gene conversion. One end of the chromosome consists of a putative bloodstream-form variant surface glycoprotein (VSG) gene expression site that appears truncated and degenerate. The other chromosome end carries VSG and expression site-associated genes and pseudogenes over 50 kb of subtelomeric sequence where, unusually, the telomere-proximal VSG gene is oriented away from the telomere. Our analysis includes the cataloguing of minor genetic variations between the chromosome I homologues and an estimate of crossing-over frequency during genetic exchange. Genetic polymorphisms are exceptionally rare in sequences located within and around the strand-switches between several gene clusters.
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Registered trials
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