ArticleNucleic acids research2003
The sequence and analysis of Trypanosoma brucei chromosome II.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease.PLoS pathogens · 2021Article
- Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Journal of molecular biology · 2020Review
- Trypanosomes can initiate nuclear export co-transcriptionally.Nucleic acids research · 2019Article
- Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes.Current genomics · 2018Review
- Transposons to toxins: the provenance, architecture and diversification of a widespread class of eukaryotic effectors.Nucleic acids research · 2016Article
- Advancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping.Molecular and biochemical parasitology · 2015Article
- Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169.Journal of cell science · 2008Article
- Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map.Genome biology · 2008Article
- Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes.Eukaryotic cell · 2007Article
- Genome comparison using Gene Ontology (GO) with statistical testing.BMC bioinformatics · 2006Article
- Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites.Journal of molecular evolution · 2005Article
- The genome of the kinetoplastid parasite, Leishmania major.Science (New York, N.Y.) · 2005Article
- A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes.RNA (New York, N.Y.) · 2005Article
- The genetic map and comparative analysis with the physical map of Trypanosoma brucei.Nucleic acids research · 2005Article
- Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor.Nucleic acids research · 2005Article
- Functional characterization of a Trypanosoma brucei TATA-binding protein-related factor points to a universal regulator of transcription in trypanosomes.Molecular and cellular biology · 2004Article
- The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes.Genome research · 2004Article
- TbAGO1, an argonaute protein required for RNA interference, is involved in mitosis and chromosome segregation in Trypanosoma brucei.BMC biology · 2003Article
- The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.Nucleic acids research · 2003Article
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Authors and funding
44 authors.
Funding
Abstract
We report here the sequence of chromosome II from Trypanosoma brucei, the causative agent of African sleeping sickness. The 1.2-Mb pairs encode about 470 predicted genes organised in 17 directional clusters on either strand, the largest cluster of which has 92 genes lined up over a 284-kb region. An analysis of the GC skew reveals strand compositional asymmetries that coincide with the distribution of protein-coding genes, suggesting these asymmetries may be the result of transcription-coupled repair on coding versus non-coding strand. A 5-cM genetic map of the chromosome reveals recombinational 'hot' and 'cold' regions, the latter of which is predicted to include the putative centromere. One end of the chromosome consists of a 250-kb region almost exclusively composed of RHS (pseudo)genes that belong to a newly characterised multigene family containing a hot spot of insertion for retroelements. Interspersed with the RHS genes are a few copies of truncated RNA polymerase pseudogenes as well as expression site associated (pseudo)genes (ESAGs) 3 and 4, and 76 bp repeats. These features are reminiscent of a vestigial variant surface glycoprotein (VSG) gene expression site. The other end of the chromosome contains a 30-kb array of VSG genes, the majority of which are pseudogenes, suggesting that this region may be a site for modular de novo construction of VSG gene diversity during transposition/gene conversion events.
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