ReviewCurrent allergy and asthma reports2003
Exposure, sensitization, and mechanisms of fungus-induced asthma.
Review in Current allergy and asthma reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Immunopathologic Role of Fungi in Chronic Rhinosinusitis.International journal of molecular sciences · 2023Review
- TLR-2 expression and dysregulated human Treg/Th17 phenotype in Aspergillus flavus infected patients of chronic rhinosinusitis with nasal polyposis.Microbial cell factories · 2020Article
- Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi.Frontiers in immunology · 2019Review
- The Plant Proteinase InhibitorBioMed research international · 2018Article
- Airway epithelial anion secretion and barrier function following exposure to fungal aeroallergens: role of oxidative stress.American journal of physiology. Cell physiology · 2017Article
- The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Allergic aspergillosis of the respiratory tract.European respiratory review : an official journal of the European Respiratory Society · 2014Review
- ATP release and Ca2+ signalling by human bronchial epithelial cells following Alternaria aeroallergen exposure.The Journal of physiology · 2013Article
- Circulating human basophils lack the features of professional antigen presenting cells.Scientific reports · 2013Article
- Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors.PloS one · 2013Article
- Assessing allergenic fungi in house dust by floor wipe sampling and quantitative PCR.Indoor air · 2011Article
- Fungal proteases and their pathophysiological effects.Mycopathologia · 2011Review
- Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Prevalence of fungal infection among Iranian patients with chronic sinusitis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2011Article
- Regulation of TLR2 expression and function in human airway epithelial cells.The Journal of membrane biology · 2009Article
- Diversity and significance of mold species in Norwegian drinking water.Applied and environmental microbiology · 2006Article
- Innate immune responses to environmental allergens.Clinical reviews in allergy & immunology · 2006Review
- Antifungal immune reactivity in nasal polyposis.Infection and immunity · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy individuals are continuously exposed to fungal biomass, which includes live and dead spores and fungal debris that is entrapped in the airways. In patients with asthma and/or atopy, exposure to fungal biomass might result in age-dependent sensitization and asthmatic reactions. Interaction with Toll-like receptors (TLRs) of the innate immune defense (alveolar macrophages and epithelial cells) and protease-activated receptors (PARs) determine the effectiveness of elimination of fungal material. The association of sensitization to Alternaria with severe asthma is discussed in relation to the age-dependent sensitization, rate of release of allergens from spores, and activity of its proteases. A model is described concerning the influence of polymorphic genes for airway hyperresponsiveness (AHR) and atopy, showing a cumulating influence on susceptibility for allergen-induced asthma, and explaining that fungus-induced airway obstruction is mainly associated with more severe asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.