ArticleArthritis and rheumatism2003
A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis.
Article in Arthritis and rheumatism, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis.Antioxidants (Basel, Switzerland) · 2021Article
- Influence of hydrocarbon oil structure on adjuvanticity and autoimmunity.Scientific reports · 2017Article
- Rheumatoid arthritis: identifying and characterising polymorphisms using rat models.Disease models & mechanisms · 2016Review
- Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research.BMC genomics · 2014Article
- Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.Genes and immunity · 2012Article
- Finemapping of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus.Genes and immunity · 2010Article
- Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Article
- Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- DA rats from two colonies differ genetically and in their arthritis susceptibility.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the genetic regulation of collagen-induced arthritis (CIA) with that of pristane-induced arthritis (PIA) in rats.
methodsA genome-wide linkage analysis of an (E3 x DA)DA backcross of rats with CIA (n = 364 male rats; the same strain combinations as previously used to determine the genetic control of PIA) was performed. The strongest loci in both CIA and PIA (i.e., Cia12/Pia4 and Cia13/Pia7) were isolated in congenic strains. Susceptibility in both congenic strains was tested in rats with CIA and in rats with PIA.
resultsWe found a striking, although not complete, similarity of the arthritis-controlling loci in CIA and in PIA, as well as the previously defined loci associated with cartilage destruction, antibody production, and the acute-phase response. All major PIA quantitative trait loci (QTLs) identified in early severe arthritis were also strong regulators of CIA. The 2 strongest QTLs, Cia12/Pia4 on chromosome 12 and Cia13/Pia7 on chromosome 4, were also analyzed in congenic strains with DA or E3 as the background genome. Consistent with the results of linkage analysis, the congenic strain experiments showed that the chromosome 4 locus was more penetrant in CIA than in PIA, while the chromosome 12 locus almost completely dominated the control of PIA severity.
conclusionThe underlying genetic control of CIA was found to have many, but not all, pathogenic mechanisms in common with PIA, despite the use of a cartilage-specific antigen (type II collagen) to induce CIA but not PIA.
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