ArticleJournal of clinical microbiology2003
Geographic diversity among genotypes of Entamoeba histolytica field isolates.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Amoebiasis in Iran: a systematic review and meta-analysis.Epidemiology and infection · 2018Pooled it
- Investigating genetic polymorphism in E. histolytica isolates with distinct clinical phenotypes.Parasitology research · 2023Article
- Prevalence and molecular characterization of Entamoeba moshkovskii in diarrheal patients from Eastern India.PLoS neglected tropical diseases · 2023Article
- Attenuation of In Vitro and In Vivo Virulence Is Associated with Repression of Gene Expression of AIG1 Gene inPathogens (Basel, Switzerland) · 2023Article
- Analysis of D-A locus of tRNA-linked short tandem repeats reveals transmission of Entamoeba histolytica and E. dispar among students in the Thai-Myanmar border region of northwest Thailand.PLoS neglected tropical diseases · 2021Article
- Article
- AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica.PLoS pathogens · 2018Article
- Membrane Trafficking Modulation during Entamoeba Encystation.Scientific reports · 2017Article
- TheCurrent tropical medicine reports · 2016Article
- Entamoeba histolytica and Entamoeba dispar infection in Mexican school children: genotyping and phylogenetic relationship.BMC infectious diseases · 2016Article
- Burden of Liver Abscess and Survival Risk Score in Thailand: A Population-Based Study.The American journal of tropical medicine and hygiene · 2016Observational
- Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica.Frontiers in immunology · 2016Review
- Evolutionary genomics and population structure of Entamoeba histolytica.Computational and structural biotechnology journal · 2014Review
- Correlation between genotypes of tRNA-linked short tandem repeats in Entamoeba nuttalli isolates and the geographical distribution of host rhesus macaques.Parasitology research · 2014Article
- Genomic distribution of SINEs in Entamoeba histolytica strains: implication for genotyping.BMC genomics · 2013Article
- Unique short tandem repeat nucleotide sequences in Entamoeba histolytica isolates from China.Parasitology research · 2012Article
- A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence.BMC microbiology · 2012Article
- Evidence for a link between locus R-R sequence type and outcome of infection with Entamoeba histolytica.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2012Article
- Polymorphism in two short tandem repeat loci (R-R and S-Q) linked to tRNA genes in Entamoeba dispar isolates.Gastroenterology and hepatology from bed to bench · 2012Article
- Sequence Diversity in tRNA Gene Locus A-L among Iranian Isolates of Entamoeba dispar.Iranian journal of parasitology · 2012Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It has been known that only 5 to 10% of those infected with Entamoeba histolytica develop symptomatic disease. However, the parasite and the host factors that determine the onset of disease remain undetermined. Molecular typing by using polymorphic genetic loci has been proven to aid in the close examination of the population structure of E. histolytica field isolates in nature. In the present study, we analyzed the genetic polymorphisms of two noncoding loci (locus 1-2 and locus 5-6) and two protein-coding loci (chitinase and serine-rich E. histolytica protein [SREHP]) among 79 isolates obtained from different geographic regions, mainly Japan, Thailand, and Bangladesh. When the genotypes of the four loci were combined for all isolates that we have analyzed so far (overlapping isolates from mass infection events were excluded), a total of 53 different genotypes were observed among 63 isolates. The most remarkable and extensive variations among the four loci was found in the SREHP locus; i.e., 34 different genotypes were observed among 52 isolates. These results demonstrate that E. histolytica has an extremely complex genetic structure independent of geographic location. Our results also show that, despite the proposed transmission of other sexually transmitted diseases, including human immunodeficiency virus infection, from Thailand to Japan, the spectra of the genotypes of the E. histolytica isolates from these two countries are distinct, suggesting that the major E. histolytica strains prevalent in Japan at present were likely introduced from countries other than Thailand. Although the genetic polymorphism of the SREHP locus was previously suggested to be closely associated with the clinical presentation, e.g., colitis or dysentery and liver abscess, no association between the clinical presentation and the SREHP genotype at either the nucleotide or the predicted amino acid level was demonstrated.
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