Evidence map›Paper›PMID 12902163›Full record

ArticleTrends in genetics : TIG2003

Maneuvering for advantage: the genetics of mouse susceptibility to virus infection.

Seung-Hwan Lee, Ken Dimock, Douglas A Gray, Nicole Beauchemin, Kathryn V Holmes, Majid Belouchi, John Realson, Silvia M Vidal

Abstract read
In one paragraph

Article in Trends in genetics : TIG, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seung-Hwan LeeDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5.
Ken Dimock
Douglas A Gray
Nicole Beauchemin
Kathryn V Holmes
Majid Belouchi
John Realson
Silvia M Vidal

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic studies of host susceptibility to infection contribute to our understanding of an organism's response to pathogens at the immunological, cellular, and molecular levels. In this review we describe how the study of host genetics in mouse models has helped our understanding of host defense mechanisms against viral infection, and how this knowledge can be extended to human infections. We focus especially on the innate mechanisms that function as the host's first line of defense against infection. We also discuss the main issues that confront this field, as well as its future.

Indexed as

Genetic Predisposition to DiseaseAnimalsCell MembraneChromosome MappingImmunity, InnateKiller Cells, NaturalMiceVirus DiseasesVirus Replication

Identifiers

PMID12902163
PMCPMC7127612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.