Trial reportJournal of the International Neuropsychological Society : JINS2003
Neuropsychological deficits associated with Alzheimer's disease in the very-old: discrepancies in raw vs. standardized scores.
Trial report in Journal of the International Neuropsychological Society : JINS, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- FAS and CFL forms of verbal fluency differ in difficulty: a meta-analytic study.Applied neuropsychology · 2008Pooled it
- Mind-Body Interventions as Modulators of Neural Connectivity and Cognition in Individuals at Risk for Alzheimer's Disease: A Systematic Review.Annals of neurosciences · 2026Review
- Commonalities and Divergences in the Cognitive Profiles of Autism and Dementia: Protocol for a Narrative Literature Review.JMIR research protocols · 2026Article
- Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator.Molecular psychiatry · 2025Article
- Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.Brain pathology (Zurich, Switzerland) · 2024Review
- Weak Social Networks in Late Life Predict Incident Alzheimer's Disease: The Kuakini Honolulu-Asia Aging Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Abnormal Functional Hierarchies of EEG Networks in Familial and Sporadic Prodromal Alzheimer's Disease During Visual Short-Term Memory Binding.Frontiers in neuroimaging · 2022Article
- Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort.Brain and behavior · 2021Article
- Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression.Frontiers in genetics · 2020Article
- Selection of Normative Group Affects Rates of Mild Cognitive Impairment in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2018Article
- Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old.Dementia and geriatric cognitive disorders · 2018Article
- APOE Affects the Volume and Shape of the Amygdala and the Hippocampus in Mild Cognitive Impairment and Alzheimer's Disease: Age Matters.Journal of Alzheimer's disease : JAD · 2015Article
- APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- Functional connectivity during recognition memory in individuals genetically at risk for Alzheimer's disease.Human brain mapping · 2013Article
- Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease.Neurology · 2011Article
- Emotional working memory in Alzheimer's disease patients.Dementia and geriatric cognitive disorders extra · 2011Article
- Neuropsychological assessment of dementia.Annual review of psychology · 2009Review
- Neuropsychological contributions to the early identification of Alzheimer's disease.Neuropsychology review · 2008Review
- Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study.Neuroradiology · 2007Article
- Overcoming barriers in cognitive assessment of Alzheimer's disease.Dementia & neuropsychologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The profiles of neuropsychological deficits associated with Alzheimer's disease (AD) in Young-Old (M age and 70) and Very-Old (M age > 80) patients were compared, along with possible modifying effects of apolipoprotein E (APOE) genotype on these profiles. A comprehensive battery of neuropsychological tests was administered to the two AD patient groups (Young-Old: n = 33; Very-Old: n = 48) and their respective age-matched normal control (NC) groups who remained free of dementia on follow-up examinations over a 1 to 10 year period (Young-Old: n = 43; Very-Old: n = 36). AD and NC groups did not differ in education levels or gender distributions. Young-Old AD and Very-Old AD groups were comparable in education, gender, dementia severity, and disease duration. Results showed that both AD groups achieved comparable raw scores on all the neuropsychological measures. However, when scores were standardized on the basis of performance of their respective NC groups (i.e., age-corrected z scores), Very-Old AD patients significantly outperformed Young-Old AD patients on tests of executive functions, visuospatial skills, and delayed memory. Furthermore, the relationship between age and memory and executive function deficits in AD was modified by APOE genotype. These data suggest that the profile of neuropsychological deficits associated with AD in the Very-Old lacks the disproportionate saliency of episodic memory and executive function deficits typical of the Young-Old.
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