ArticleThe Journal of experimental medicine2003
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 149 citations in OpenAlex.
- Neuroimmune Mechanisms in Equine Asthma: Primary Inflammatory Triggers, Neuroimmune Modulation and Chronic Airway Remodelling.Animals : an open access journal from MDPI · 2026Review
- Maternal-prenatal gut microbiome-systemic metabolome perturbations and TGenome medicine · 2026Article
- ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket.Development (Cambridge, England) · 2025Article
- Is There a Relationship Between Serum BDNF Levels, Disease Severity, and Psychiatric Symptoms in Adolescents with Atopic Dermatitis?Children (Basel, Switzerland) · 2025Article
- Biologics and airway remodeling in asthma: early, late, and potential preventive effects.Allergy · 2025Review
- New insight of square stepping exercise in immune fine-tuning for anticipating emerging pandemics.Animal cells and systems · 2024Review
- Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases.International journal of molecular sciences · 2023Review
- ProBDNF and its receptors in immune-mediated inflammatory diseases: novel insights into the regulation of metabolism and mitochondria.Frontiers in immunology · 2023Review
- Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma.Frontiers in immunology · 2022Review
- Effect of BDNF on airway inflammation in a rat model of COPD.Experimental and therapeutic medicine · 2021Article
- Understanding Vernal Keratoconjunctivitis: Beyond Allergic Mechanisms.Life (Basel, Switzerland) · 2021Review
- BDNF Acts as a Prognostic Factor Associated with Tumor-Infiltrating Th2 Cells in Pancreatic Adenocarcinoma.Disease markers · 2021Article
- Neurotrophin Regulation and Signaling in Airway Smooth Muscle.Advances in experimental medicine and biology · 2021Article
- Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration andJournal of personalized medicine · 2020Article
- Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps.Allergy, asthma & immunology research · 2020Article
- Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Candidate genes involved in metastasis of colon cancer identified by integrated analysis.Cancer medicine · 2019Article
- Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Molecular neurobiology · 2017Review
- The nasal methylome and childhood atopic asthma.The Journal of allergy and clinical immunology · 2017Article
- Brain-derived neurotrophic factor modulates immune reaction in mice with peripheral nerve xenotransplantation.Neuropsychiatric disease and treatment · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations in allergic diseases. Neurotrophin levels are up-regulated endobronchially after allergen challenge. This coincides with an influx of activated eosinophils into the bronchial lumen. These eosinophils have an increased viability and CD69 expression 18 h after segmental allergen provocation (SAP) which is not present in peripheral blood. To investigate whether these observations are related we studied the influence of neurotrophins on eosinophil function in allergic asthma. Incubation with NGF, BDNF, NT-3, or NT-4 caused a significant increase in the viability and CD69 expression of isolated eosinophils from bronchoalveolar lavage fluid (BALF) but not from peripheral blood, suggesting a unique sensitivity of endobronchial eosinophils to neurotrophins. To elucidate the underlying mechanisms expression of the neurotrophin receptors p75NTR, trkA, trkB, and trkC on eosinophils was analyzed by RT-PCR and immunocytology. After SAP expression of all neurotrophin receptors was markedly elevated on eosinophils from BALF. Our findings suggest that neurotrophin-mediated activation of bronchial eosinophils might play a role in the regulation of eosinophilic inflammation in allergic asthma.
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