ArticleThe Journal of cell biology2003
Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
- Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers.Nature communications · 2023Article
- Article
- Mechanisms of node of Ranvier assembly.Nature reviews. Neuroscience · 2021Review
- Spike Generators and Cell Signaling in the Human Auditory Nerve: An Ultrastructural, Super-Resolution, and Gene Hybridization Study.Frontiers in cellular neuroscience · 2021Article
- Review
- Guillain-Barré syndrome, transverse myelitis and infectious diseases.Cellular & molecular immunology · 2018Review
- Olfactory receptor neuronal dendrites become mostly intra-sustentacularly enwrapped upon maturity.Journal of anatomy · 2018Article
- Damage of hippocampal neurons in rats with chronic alcoholism.Neural regeneration research · 2014Article
- Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway.Neural regeneration research · 2012Article
- GABA-B receptors in the PNS have a role in Schwann cells differentiation?Frontiers in cellular neuroscience · 2012Article
- Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length.Molecular and cellular neurosciences · 2011Article
- N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination.Development (Cambridge, England) · 2011Article
- Article
- Myelination and regional domain differentiation of the axon.Results and problems in cell differentiation · 2009Review
- Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination.The Journal of cell biology · 2007Article
- Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms.The Journal of cell biology · 2007Article
- The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.Molecular biology of the cell · 2007Article
- Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nodes of Ranvier are specialized, highly polarized axonal domains crucial to the propagation of saltatory action potentials. In the peripheral nervous system, axo-glial cell contacts have been implicated in Schwann cell (SC) differentiation and formation of the nodes of Ranvier. SC microvilli establish axonal contact at mature nodes, and their components have been observed to localize early to sites of developing nodes. However, a role for these contacts in node formation remains controversial. Using a myelinating explant culture system, we have observed that SCs reorganize and polarize microvillar components, such as the ezrin-binding phosphoprotein 50 kD/regulatory cofactor of the sodium-hydrogen exchanger isoform 3 (NHERF-1), actin, and the activated ezrin, radixin, and moesin family proteins before myelination in response to inductive signals. These components are targeted to the SC distal tips where live cell imaging reveals novel, dynamic growth cone-like behavior. Furthermore, localized activation of the Rho signaling pathway at SC tips gives rise to these microvillar component-enriched "caps" and influences the efficiency of node formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.