ArticleNeurogenetics2003
Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2.
Article in Neurogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Meta-analysis of the association between urokinase-plasminogen activator gene rs2227564 polymorphism and Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2013Pooled it
- Towards compendia of negative genetic association studies: an example for Alzheimer disease.Human genetics · 2006Pooled it
- Novel mouse line with D277N mutation in theFrontiers in cell and developmental biology · 2026Article
- Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Searching for Genetic Biomarkers for Hereditary Angioedema Due to C1-Inhibitor Deficiency (C1-INH-HAE).Frontiers in allergy · 2022Article
- Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly.Scientific reports · 2021Article
- Hemostasis components in cerebral amyloid angiopathy and Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease.Frontiers in human neuroscience · 2021Article
- Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review).International journal of molecular medicine · 2019Review
- Unraveling the genes implicated in Alzheimer's disease.Biomedical reports · 2017Article
- Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms.American journal of Alzheimer's disease and other dementias · 2015Article
- Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis.Molecular medicine reports · 2015Article
- The study of t-PA, u-PA and PAI-1 genes polymorphisms in patients with abdominal aortic aneurysm.Molecular biology reports · 2014Article
- Association of calcium urolithiasis with urokinase P141L and 3'-UTR C>T polymorphisms in a Japanese population.Urolithiasis · 2013Article
- Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population.Neural regeneration research · 2012Article
- Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1.Human molecular genetics · 2012Article
- PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells.Molecular systems biology · 2012Article
- Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population.PloS one · 2012Article
- A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data.BMC genomics · 2010Article
- The molecular genetics of sirtuins: association with human longevity and age-related diseases.International journal of molecular epidemiology and genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urokinase-type plasminogen activator (uPA) converts plasminogen to plasmin. Plasmin is involved in processing of amyloid precursor protein and degrades secreted and aggregated amyloid-beta, a hallmark of Alzheimer disease (AD). PLAU, the gene encoding uPA, maps to chromosome 10q22.2 between two regions showing linkage to late-onset AD (LOAD). We genotyped a frequent C/T single nucleotide polymorphism in codon 141 of PLAU (P141L) in 347 patients with LOAD and 291 control subjects. LOAD was associated with homozygous C/C PLAU genotype in the whole sample (chi2=15.7, P=0.00039, df 2), as well as in all sub-samples stratified by gender or APOE epsilon4 carrier status (chi2> or = 6.84, P< or =0.033, df 2). Odds ratio for LOAD due to homozygosity C/C was 1.89 (95% confidence interval 1.37-2.61). PLAU is a promising new candidate gene for LOAD, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.