ArticleHistochemistry and cell biology2003
Expression of glutamate transporters in human and rat retina and rat optic nerve.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Synapse Dysfunctions in Multiple Sclerosis.International journal of molecular sciences · 2023Review
- Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration.Life (Basel, Switzerland) · 2022Review
- Glutamate Transporters: Expression and Function in Oligodendrocytes.Neurochemical research · 2020Article
- Immunohistochemical Localization of GFAP and Glutamate Regulatory Proteins in Chick Retina and Their Levels of Expressions in Altered Photoperiods.Cellular and molecular neurobiology · 2017Article
- Glial cell interactions and glaucoma.Current opinion in ophthalmology · 2015Review
- Limited energy supply in Müller cells alters glutamate uptake.Neurochemical research · 2014Article
- Functional properties of the retinal glutamate transporters GLT-1c and EAAT5.The Journal of biological chemistry · 2014Article
- GABA and Glutamate Uptake and Metabolism in Retinal Glial (Müller) Cells.Frontiers in endocrinology · 2013Article
- The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.Biophysical journal · 2011Article
- Expression and distribution of 'high affinity' glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system.Journal of anatomy · 2008Article
- Synaptic regulation of the light-dependent oscillatory currents in starburst amacrine cells of the mouse retina.Journal of neurophysiology · 2008Article
- EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders.Molecular psychiatry · 2007Review
- Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice.Proteome science · 2007Article
- Apical localization of glutamate in GLAST-1, glutamine synthetase positive ciliary body nonpigmented epithelial cells.Clinical ophthalmology (Auckland, N.Z.) · 2007Article
- Muller cell expression of glutamate cycle related proteins and anti-apoptotic proteins in early human retinal development.The British journal of ophthalmology · 2006Article
- News and views in Histochemistry and Cell Biology.Histochemistry and cell biology · 2004Review
- Innovative techniques and applications in histochemistry and cell biology.Histochemistry and cell biology · 2003Review
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
l-Glutamate is the major excitatory transmitter in the vertebrate retina and plays a central role in the transmission of the various retinal neurons. Glutamate is removed from the extracellular space by at least five different glutamate transporters. The cellular distribution of these has been studied so far mainly using immunocytochemistry. In the present study non-radioactive in situ hybridisation using complementary RNA probes was applied in order to identify the cell types of rat retina and optic nerve expressing generic GLT1, GLT1 variant (GLT1v or GLT1B), GLAST and EAAC1. The results were compared with immunocytochemical data achieved using affinity-purified antibodies against transporter peptides. In the immunohistochemical studies the human retina was included. The study showed that in the rat retina GLT1v and EAAC1 were coexpressed in various cell types, i.e. photoreceptor, bipolar, horizontal, amacrine, ganglion and Müller cells, whereas GLAST was only detected in Müller cells and astrocytes. In the rat optic nerve GLT1v and EAAC1 were preferentially expressed in oligodendrocytes, whereas GLAST was revealed to be present mainly in astrocytes. Generic GLT1 could not be detected in the retina or optic nerve. The cellular distribution of glutamate transporters (only immunocytochemistry) in the human retina was very similar to that of the rat retina. Remarkable results of our studies were that generic GLT1 was not detectable in the rat (and human) retina and that GLT1v and EAAC1 were demonstrable in most cell types of the retina (including photoreceptor cells and their terminals).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.