ArticleDevelopment genes and evolution2003
Isolation and characterization of two T-box genes from sponges, the phylogenetically oldest metazoan taxon.
Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 59 citations in OpenAlex.
- Case report: A novelFrontiers in genetics · 2022Article
- Article
- Early evolution of the T-box transcription factor family.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin.PLoS genetics · 2011Article
- Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki.Molecular biology and evolution · 2011Article
- Expansion, diversification, and expression of T-box family genes in Porifera.Development genes and evolution · 2010Article
- A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.Developmental biology · 2010Article
- Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs.Development genes and evolution · 2008Article
- Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Molecular control of serial module formation along the apical-basal axis in the sponge Lubomirskia baicalensis: silicateins, mannose-binding lectin and mago nashi.Development genes and evolution · 2006Article
- Conservation and co-option in developmental programmes: the importance of homology relationships.Frontiers in zoology · 2005Article
- 16S rRNA phylogeny of sponge-associated cyanobacteria.Applied and environmental microbiology · 2005Article
- Evolution of metazoan cell junction proteins: the scaffold protein MAGI and the transmembrane receptor tetraspanin in the demosponge Suberites domuncula.Journal of molecular evolution · 2004Article
- Embryonic cleavage cycles: how is a mouse like a fly?Current biology : CB · 2004Review
- The molecular basis for the evolution of the metazoan bodyplan: extracellular matrix-mediated morphogenesis in marine demosponges.Journal of molecular evolution · 2003Article
- Evo-devo of non-bilaterian animals.Genetics and molecular biologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now well established that all metazoan phyla derived from one common ancestor, the hypothetical Urmetazoa. Due to the basal position of Porifera (Demospongiae) in the phylogenetic tree of Metazoa, studies on the mechanisms controlling the development of these animals can provide clues on the understanding of the origin of multicellular animals and on how the first organization of the body plan evolved. In this report we describe the isolation and genomic characterization of two T-box genes from the siliceous sponge Suberites domuncula. The phylogenetic analysis classifies one into the subfamily of Brachyury, Sd-Bra, and the second into the Tbx2 subfamily, Sd-Tbx2. Analyses of the Sd-Bra and Sd-Tbx2 sequences and their intron-exon structures demonstrate their basal position in the phylogeny of the T-box family, and allows us to hypothesize a model of the phylogenetic evolution of all T-box genes. Furthermore, we report the presence of two different products of alternative splicing of Sd-Bra, and demonstrate that they exist in different phosphorylation and glycosylation states in the sponge tissue. Sd-Bra expression in tissue and 3D-cell aggregates (primmorphs) is analyzed, suggesting that Sd-Bra might also have a role in Porifera morphogenesis.
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