ArticleVirchows Archiv : an international journal of pathology2003
CD34+ fibrocytes in tubular carcinomas and radial scars of the breast.
Article in Virchows Archiv : an international journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Diagnostic Biomarkers in Oral Verrucous Carcinoma: A Systematic Review.Pathology oncology research : POR · 2017Pooled it
- Article
- CD34+ Stromal Cells/Telocytes as a Source of Cancer-Associated Fibroblasts (CAFs) in Invasive Lobular Carcinoma of the Breast.International journal of molecular sciences · 2021Article
- Prognostic relevance of the loss of stromal CD34 positive fibroblasts in invasive lobular carcinoma of the breast.Virchows Archiv : an international journal of pathology · 2020Article
- Fibrocytes in the Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- Presence/Absence and Specific Location of Resident CD34+ Stromal Cells/Telocytes Condition Stromal Cell Development in Repair and Tumors.Frontiers in cell and developmental biology · 2020Article
- Radial scars and subsequent breast cancer risk: results from the Nurses' Health Studies.Breast cancer research and treatment · 2013Article
- Stromal expression of CD34, α-smooth muscle actin and CD26/DPPIV in squamous cell carcinoma of the skin: a comparative immunohistochemical study.Pathology oncology research : POR · 2012Article
- Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis.The international journal of biochemistry & cell biology · 2010Review
- CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.Virchows Archiv : an international journal of pathology · 2008Article
- CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder.Virchows Archiv : an international journal of pathology · 2007Article
- The role of circulating fibrocytes in fibrosis.Current rheumatology reports · 2006Review
- Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast.Virchows Archiv : an international journal of pathology · 2005Article
- A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression.Journal of mammary gland biology and neoplasia · 2004Review
- CD34+ fibrocytes, alpha-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx.Virchows Archiv : an international journal of pathology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was undertaken to analyze whether and to what extent CD34+ fibrocytes and alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts occur in the stroma of radial scars and tubular carcinoma of the breast. We investigated a total of 24 radial scars obtained from 23 females and a total of 43 tubular carcinomas. All tubular carcinomas showed a virtually complete loss of CD34+ fibrocytes paralleled by a gain of alpha-SMA-positive myofibroblasts. The peripheral parts of radial scars harbored CD34+ fibrocytes comparable to normal breast tissue. In 23 of 24 radial scars, the central core was characterized by a loss of CD34+ fibrocytes accompanied by the presence of alpha-SMA-positive myofibroblasts in six cases, a pattern that up to now has only been described in malignant breast lesions. This finding underlines the close relationship between tubular carcinomas and radial scars. We conclude CD34- and alpha-SMA immunohistochemistry to be valuable adjunctive tools in distinguishing radial scars from tubular carcinomas. In the present study, the presence of CD34+ fibrocytes excluded malignancy. The absence of CD34+ fibrocytes paralleled by the presence of alpha-SMA myofibroblasts indicated malignancy in most cases, although it has to be carefully considered that in a minority of cases (6 of 24) the central core of radial scars may disclose this stromal composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.