ArticleThe Plant cell2003
Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
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133 citing papers in PubMed, 399 citations in OpenAlex.
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- Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The polymerase-associated factor 1 complex modulates the growth-defense tradeoff inScience advances · 2025Article
- High Basal Expression and Dual Stress Responsiveness of Soybean (Plants (Basel, Switzerland) · 2025Article
- Recruitment, rewiring and deep conservation in flowering plant gene regulation.Nature plants · 2025Article
- Functional Identification Reveals That TaTGA16-2D Promotes Drought and Heat Tolerance.Plants (Basel, Switzerland) · 2025Article
- Salicylic acid and jasmonic acid in plant immunity.Horticulture research · 2025Article
- Transcriptome and Metabolomics Analysis Reveal the Effects of Red and Blue Light on the Physiology and Primary Medicinal Components (Liquiritin and Glycyrrhizic Acid) ofInternational journal of molecular sciences · 2025Article
- Salicylic acid-induced upregulation of AtAACT and AtMVD expression enhances triterpene biosynthesis in Athelia termitophila.World journal of microbiology & biotechnology · 2025Article
- Plant immunity to insect herbivores: mechanisms, interactions, and innovations for sustainable pest management.Frontiers in plant science · 2025Review
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- Genome-wide identification of bZIP transcription factors in 12 Rosaceae species and modeling of novel mechanisms of EjbZIPs response to salt stress.The plant genome · 2024Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efforts to elucidate the contributions by transcription factors to plant gene expression will require increasing knowledge of their specific in vivo regulatory associations. We are systematically investigating the role of individual TGA factors in the transcriptional control of pathogenesis-related (PR) defense genes, whose expression is stimulated in leaves by salicylic acid (SA) through a stimulus pathway involving NPR1. We focused on PR-1 because its SA-induced expression in Arabidopsis is mediated by an as-1-type promoter cis element (LS7) that is recognized in vitro by TGA factors. We found that two NPR1-interacting TGA factors, TGA2 and TGA3, are the principal contributors to an LS7 binding activity of leaves that is enhanced by SA through NPR1. The relevance of these findings to PR-1 expression was investigated by the use of chromatin immunoprecipitation, which demonstrated that in vivo these TGA factors are strongly recruited in an SA- and NPR1-dependent manner to the LS7-containing PR-1 promoter. Significantly, the timing of promoter occupancy by these factors is linked to the SA-induced onset and sustained expression of PR-1. Because leaf transfection assays indicate that TGA3 activates transcription, as noted previously for TGA2, these two TGA factors are predicted to make positive contributions to the expression of this target gene. Thus, the findings presented here distinguish among different modes of regulation by these transcription factors and provide strong support for their direct role in the stimulus-activated expression of an endogenous defense gene.
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