ArticleProceedings of the National Academy of Sciences of the United States of America2003
Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
233 citing papers in PubMed, 534 citations in OpenAlex.
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- Facultative polyandry under heat stress and the evolutionary potential for climate-driven shifts in mating systems.Heredity · 2025Article
- Trade-off between antibacterial immune defense and oogenesis progression in female Drosophila melanogaster.Genetics · 2025Article
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- A novel male accessory gland peptide reduces female post-mating receptivity in the brown planthopper.PLoS genetics · 2025Article
- Triggering and modulation of a complex behavior by a single peptidergic command neuron inProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Cuticular hydrocarbons promote desiccation resistance by preventing transpiration in Drosophila melanogaster.The Journal of experimental biology · 2024Article
- Effects of sex, mating status, and genetic background on circadian behavior inbioRxiv : the preprint server for biology · 2024Article
- Mating reconciles fitness and fecundity by switching diet preference in flies.Nature communications · 2024Article
- Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma ineLife · 2024Article
- Sex peptide receptor is not required for refractoriness to remating or induction of egg laying in Aedes aegypti.Genetics · 2024Article
- The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions.Molecular biology and evolution · 2024Article
- Male manipulation impinges on social-dependent tumor suppression in Drosophila melanogaster females.Scientific reports · 2024Article
- Long-term neuropeptide modulation of female sexual drive via the TRP channel inProceedings of the National Academy of Sciences of the United States of America · 2024Article
173 more citing papers are in PubMed but not listed here.
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2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mating elicits two major changes in the reproductive behavior of many insect females. The egg-laying rate increases and the readiness to accept males (receptivity) is reduced. These postmating responses last approximately 1 week in Drosophila melanogaster. Males that do not transfer sperm but transfer seminal fluid during mating induce a short-term response of 1 day. The long-term response of 1 week requires the presence of sperm (sperm effect). Hence, sperm is essential for the long-term persistence of the postmating responses. Three seminal fluid peptides elicit postmating responses: ovulin, sex-peptide (SP), and DUP99B. Using the technique of targeted mutagenesis by homologous recombination, we have produced males with mutant SP genes. Here, we report that males lacking functional SP elicit only a weak short-term response. However, these males do transfer sperm. Thus, (i) SP is the major agent eliciting the short-term and the long-term postmating responses and (ii) sperm is merely the carrier for SP. The second conclusion is supported by the finding that SP binds to sperm. The 36-aa-encoding SP gene is the first small Drosophila gene knocked out with the method of homologous recombination.
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