ArticleMolecular and cellular biology2003
Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The TOPOVIBL meiotic DSB formation protein: new insights from its biochemical and structural characterization.Nucleic acids research · 2024Article
- Divergence and conservation of the meiotic recombination machinery.Nature reviews. Genetics · 2024Review
- Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.The EMBO journal · 2023Article
- TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.Nature communications · 2022Article
- Structural and functional characterization of the Spo11 core complex.Nature structural & molecular biology · 2021Article
- Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4.Life science alliance · 2018Article
- Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex.Journal of cell science · 2011Article
- Factors affecting splicing strength of yeast genes.Comparative and functional genomics · 2011Article
- Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.Genes & development · 2010Article
- Functional interactions among members of the meiotic initiation complex in fission yeast.Current genetics · 2010Article
- Tethering recombination initiation proteins in Saccharomyces cerevisiae promotes double strand break formation.Genetics · 2009Article
- Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast.Genes & development · 2008Article
- Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.Genome dynamics and stability · 2008Article
- Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae.Chromosoma · 2007Article
- AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.The EMBO journal · 2007Article
- Meiotic association between Spo11 regulated by Rec102, Rec104 and Rec114.Nucleic acids research · 2007Article
- Both conserved and non-conserved regions of Spo11 are essential for meiotic recombination initiation in yeast.Molecular genetics and genomics : MGG · 2006Article
- Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.Genetics · 2006Article
- The control of Spo11's interaction with meiotic recombination hotspots.Genes & development · 2005Article
- The signal from the initiation of meiotic recombination to the first division of meiosis.Eukaryotic cell · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Initiation of meiotic recombination in the yeast Saccharomyces cerevisiae requires at least 10 gene products. The initiation event creates double-strand breaks, which are then processed by other recombination enzymes. A variety of classical observations, such as the existence of recombination nodules, have suggested that the proteins catalyzing recombination form a complex. A variety of lines of evidence indicate that Rad50p, Mre11p, and Xrs2p interact, and genetic data suggesting interactions between Rec102p and Rec104p have been reported. It has recently been shown that Spo11p coimmunoprecipitates with Rec102p in meiosis as well. In this paper, we provide genetic and biochemical evidence that the meiosis-specific proteins Rec102p, Rec104p, and Spo11p all interact with each other in meiosis. Furthermore, we demonstrate that the interaction between Rec102p and Spo11p does not require Rec104p. Likewise, the interaction between Rec104p and Rec102p does not require Spo11p, although Spo11p may stabilize that association. The interactions suggest that Spo11p, Rec102p, and Rec104p may form a trimeric complex during the initiation of recombination.
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