ArticleMolecular and cellular biology2003
TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE SignalingOxidative medicine and cellular longevity · 2019Article
- Exploring the Potential of Venom from Nasonia vitripennis as Therapeutic Agent with High-Throughput Screening Tools.Toxins · 2015Article
- Role of WWOX and NF-κB in lung cancer progression.Translational respiratory medicine · 2013Review
- Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism.Cell death and differentiation · 2012Article
- Article
- Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-α-treated hepatocytes.The American journal of pathology · 2011Article
- A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.Molecular cell · 2011Article
- Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death.Apoptosis : an international journal on programmed cell death · 2011Article
- Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1.Infection and immunity · 2009Article
- Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1.Molecular immunology · 2008Article
- Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.American journal of respiratory cell and molecular biology · 2008Article
- Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression.Molecular and cellular biology · 2006Article
- Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase.Molecular and cellular biology · 2005Article
- TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) is one of the key factors that mediate TNF signaling. The deletion of TRAF2 renders cells more sensitive to TNF-induced apoptosis. Although TRAF2 is known to be required for TNF-induced JNK and NF-kappaB activation, the underlying mechanism of the increased sensitivity of TRAF2 null cells (TRAF2(-/-)) to TNF-induced apoptosis is not fully understood. To study the underlying mechanism, we examined the difference in gene expression between TRAF2(-/-) and wild-type fibroblast cells by using microarray technology. We found that one of the genes whose expression was dramatically decreased in TRAF2(-/-) cells was the lung Krüppel-like factor (LKLF). Our results indicate that the expression of LKLF requires TRAF2 but is independent of TNF signaling. Although it appears that TRAF2 regulates the expression of the LKLF gene at the transcription level, TRAF2 does not function as a transcription factor itself. Our results suggest that TRAF2 regulates LKLF expression through the mitogen-activated protein kinase p38 pathway. More importantly, ectopic expression of LKLF in TRAF2(-/-) cells protected cells against TNF-induced apoptosis. These results reveal a novel aspect of TRAF2 function: by regulating the expression of genes, such as LKLF, TRAF2 controls cell sensitivity to apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.