Evidence map›Paper›PMID 12897022›Full record

ArticleJournal of bacteriology2003

The Product of the fimI gene is necessary for Escherichia coli type 1 pilus biosynthesis.

Mary L Valenski, Sandra L Harris, Patricia A Spears, John R Horton, Paul E Orndorff

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. ClinicalMicroorganisms · 2022
    Review
  2. Regulation ofMicrobiology (Reading, England) · 2022
    Article
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  14. Regulation ofWorld journal of clinical infectious diseases · 2011
    Article
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  17. A genome-wide approach to identify the genes involved in biofilm formation in E. coli.DNA research : an international journal for rapid publication of reports on genes and genomes · 2007
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mary L ValenskiCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
Sandra L Harris
Patricia A Spears
John R Horton
Paul E Orndorff
North Carolina State University · US

Funding

CONTROL AND EXPRESSION OF TYPE 1 PILI IN E. COLIR01AI022223 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ORNDORFF, PAUL EDWIN · 1985 to 1999
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NIAID NIH HHS AI22223
6 · The paper itself

Abstract

Site-directed mutagenesis was employed to create lesions in fimI, a gene of uncertain function located in the chromosomal gene cluster (fim) involved in Escherichia coli type 1 pilus biosynthesis. Chromosomal fimI mutations produced a piliation-negative phenotype. Complementation analysis indicated that a fimI'-kan insertion mutation and a fimI frameshift mutation produced polarity-like effects not seen with an in-frame fimI deletion mutation. Minicell analysis associated fimI with a 16.4-kDa noncytoplasmic protein product (FimI). We conclude that FimI has a required role in normal pilus biosynthesis.

Indexed as

Adhesins, Escherichia coliAllelesEscherichia coliFimbriae, BacterialFimbriae ProteinsFrameshift MutationGenetic Complementation TestMolecular Sequence DataMutagenesis, InsertionalMutagenesis, Site-DirectedAdhesins, Escherichia coliFimbriae ProteinsFimI protein, E coli

Identifiers

PMID12897022
PMCPMC166486
OpenAlexW2146120217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.