ArticleEnvironmental health perspectives2003
Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus.
Article in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Immune function effects of dental amalgam in children: a randomized clinical trial.Journal of the American Dental Association (1939) · 2008Trial
- Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR signaling.Toxicology and applied pharmacology · 2023Article
- Systemic Lupus Erythematosus: Pathogenesis at the Functional Limit of Redox Homeostasis.Oxidative medicine and cellular longevity · 2019Review
- Mouse models of lupus: what they tell us and what they don't.Lupus science & medicine · 2018Article
- Spatial, Temporal, and Dietary Variables Associated with Elevated Mercury Exposure in Peruvian Riverine Communities Upstream and Downstream of Artisanal and Small-Scale Gold Mining.International journal of environmental research and public health · 2017Article
- Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004.Environmental health perspectives · 2016Article
- Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions.Archives of environmental & occupational health · 2016Article
- Low-dose mercury heightens early innate response to coxsackievirus infection in female mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Pesticides, chemical and industrial exposures in relation to systemic lupus erythematosus.Lupus · 2014Review
- A systems toxicology approach identifies Lyn as a key signaling phosphoprotein modulated by mercury in a B lymphocyte cell model.Toxicology and applied pharmacology · 2014Article
- Mercury alters B-cell protein phosphorylation profiles.Journal of proteome research · 2014Article
- Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity.PloS one · 2014Article
- Prevention or acceleration of type 1 diabetes by viruses.Cellular and molecular life sciences : CMLS · 2013Review
- Low-dose inorganic mercury increases severity and frequency of chronic coxsackievirus-induced autoimmune myocarditis in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- A study in balance: how microbiomes are changing the shape of environmental health.Environmental health perspectives · 2011Article
- Fetal and maternal immune responses to methylmercury exposure: a cross-sectional study.Environmental research · 2011Article
- Is dental amalgam safe for humans? The opinion of the scientific committee of the European Commission.Journal of occupational medicine and toxicology (London, England) · 2011Article
- Mercury exposure and children's health.Current problems in pediatric and adolescent health care · 2010Review
- Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways.Clinical and experimental immunology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Inorganic mercury (iHg) is known to induce autoimmune disease in susceptible rodent strains. Additionally, in inbred strains of mice prone to autoimmune disease, iHg can accelerate and exacerbate disease manifestations. Despite these well-known links between iHg and autoimmunity in animal models, no association between iHg alone and autoimmune disease in humans has been documented. However, it is possible that low-level iHg exposure can interact with disease triggers to enhance disease expression or susceptibility. To address whether exposure to iHg can alter the course of subsequent acquired autoimmune disease, we used a murine model of acquired autoimmunity, lupus-like chronic graft-versus-host disease (GVHD), in which autoimmunity is induced using normal, nonautoimmune prone donor and F1 recipient mice resistant to Hg-induced autoimmunity. Our results indicate that a 2-week exposure to low-dose iHg (20 or 200 micro g/kg every other day) to donor and host mice ending 1 week before GVHD induction can significantly worsen parameters of disease severity, resulting in premature mortality. iHg pretreatment clearly worsened chronic lupus-like disease, rather than GVHD worsening iHg immunotoxicity. These results are consistent with the hypothesis that low-level, nontoxic iHg preexposure may interact with other risk factors, genetic or acquired, to promote subsequent autoimmune disease development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.