Trial reportBritish journal of clinical pharmacology2003
A simple pain model for the evaluation of analgesic effects of NSAIDs in healthy subjects.
Trial report in British journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
- Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain.British journal of pharmacology · 2011Trial
- A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Trial
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- Sex-Related Differences in Chronic Pain: A Narrative Review by a Multidisciplinary Task Force.Medicina (Kaunas, Lithuania) · 2025Review
- Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.Scientific reports · 2023Review
- Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.Experimental brain research · 2021Article
- The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.European journal of pain (London, England) · 2019Article
- Article
- Analgesic Microneedle Patch for Neuropathic Pain Therapy.ACS nano · 2017Article
- A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models.British journal of clinical pharmacology · 2016Review
- Ultraviolet Radiation on the Skin: A Painful Experience?CNS neuroscience & therapeutics · 2016Review
- Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials.Journal of pain research · 2016Article
- Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation.PloS one · 2014Article
- The UVB cutaneous inflammatory pain model: a reproducibility study in healthy volunteers.International journal of physiology, pathophysiology and pharmacology · 2013Article
- Analgesic activity of fixed dose combinations of paracetamol with diclofenac sodium and paracetamol with tramadol on different pain models in healthy volunteers - A randomized double blind crossover study.Journal of anaesthesiology, clinical pharmacology · 2012Article
- CXCL5 mediates UVB irradiation-induced pain.Science translational medicine · 2011Article
- Placebo controlled, crossover validation study of oral ibuprofen and topical hydrocortisone- 21-acetate for a model of ultraviolet B radiation (UVR)-induced pain and inflammation.Journal of pain research · 2011Article
- Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review.British journal of clinical pharmacology · 2009Review
- [Potential antinociceptive mechanisms of botulinum toxin].Schmerz (Berlin, Germany) · 2006Review
- The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.eNeuroArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsNon-steroidal anti-inflammatory drugs (NSAIDs) are believed to counteract inflammation and inflammation-induced sensitization of nociceptors by inhibiting peripheral prostaglandin synthesis. We evaluated an experimental pain model for NSAIDs, that included an inflammatory component to mimic clinical inflammatory pain conditions.
methodsThe study was performed in a randomized, double-blind, placebo-controlled, two-way crossover design on 32 healthy volunteers. A small skin area of the proximal upper leg was irradiated with a UVB source using three times the individually estimated minimal erythema dose. Twenty hours after irradiation skin temperature, heat pain threshold and tolerance in sunburn spot were measured using a thermal sensory testing. These measurements were repeated 2 h after medication of either 800 mg ibuprofen as single oral dose or placebo capsules. Effects of ibuprofen on outcome parameters were assessed with analyses of covariance (ancova).
resultsPlacebo did not affect heat pain threshold or tolerance. By contrast, ibuprofen increased heat pain threshold by 1.092 degrees C [confidence interval (CI) 0.498, 1.695; P = 0.0008) compared with placebo. Heat pain tolerance also increased significantly by 1.618 degrees C (CI 1.062, 2.175; P = 0.0001).
conclusionThe pain model we evaluated was well tolerated in all subjects and the effects of ibuprofen were highly significant. This model is simple, sensitive to NSAIDs' effects and therefore has potential for future experimental pain studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.