ArticleOncogene2003
Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters.Nucleic acids research · 2021Article
- HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies.The Journal of experimental medicine · 2018Article
- Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes.Redox biology · 2018Article
- Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1.The Journal of steroid biochemistry and molecular biology · 2017Article
- CDKN1A histone acetylation and gene expression relationship in gastric adenocarcinomas.Clinical and experimental medicine · 2017Article
- Minireview: The versatile roles of lysine deacetylases in steroid receptor signaling.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Effects of Trichostatin A on Cumulus Expansion during Mouse Oocyte Maturation.Asian-Australasian journal of animal sciences · 2013Article
- Class I lysine deacetylases facilitate glucocorticoid-induced transcription.The Journal of biological chemistry · 2013Article
- Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells.Cell death & disease · 2013Article
- The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.Molecular cell · 2012Article
- HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.Journal of biomedicine & biotechnology · 2011Article
- Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.Cell cycle (Georgetown, Tex.) · 2010Article
- Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.Modern rheumatology · 2010Article
- Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells.Trends in biochemical sciences · 2009Review
- Two chromatin remodeling activities cooperate during activation of hormone responsive promoters.PLoS genetics · 2009Article
- Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.Molecular biology of the cell · 2008Article
- The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model.British journal of cancer · 2007Article
- Stress up-regulates neuronal expression of the herpes simplex virus type 2 large subunit of ribonucleotide reductase (R1; ICP10) by activating activator protein 1.Journal of neurovirology · 2005Article
- Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.Arthritis research & therapy · 2005Article
- Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression.The Journal of clinical investigation · 2004Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Increased histone acetylation has been associated with activated gene transcription and decreased acetylation with repression. However, there is a growing number of genes known, which are downregulated by histone deacetylase (HDAC) inhibitors through unknown mechanisms. This study examines the mechanism by which the mouse mammary tumor virus (MMTV) promoter is repressed by the HDAC inhibitor, trichostatin A (TSA). We find that this repression is transcriptional in nature and that it occurs in the presence and absence of glucocorticoids. TSA decreases MMTV transcription at a rapid rate, reaching maximum in 30-60 min. In contrast with previous reports, the repression does not correlate with an inhibition of glucocorticoid-induced nuclease hypersensitivity or NF1-binding at the MMTV promoter. Surprisingly, TSA does not induce sizable increases in histone acetylation at the MMTV promoter nor does it inhibit histone deacetylation, which accompanies deactivation of the glucocorticoid-activated MMTV promoter. Repression of MMTV transcription by TSA does not depend on the chromatin organization of the promoter because a transiently transfected MMTV promoter construct with a disorganized nucleoprotein structure was also repressed by TSA treatment. Mutational analysis of the MMTV promoter indicates that repression by TSA is mediated through the TATA box region. These results suggest a novel mechanism that involves acetylation of nonhistone proteins necessary for basal transcription.
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