ArticleProceedings of the National Academy of Sciences of the United States of America2003
The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 1 of them a synthesis that pooled it.
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Who cites it
235 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the study of juvenile hormone signaling.Frontiers in physiology · 2026Pooled it
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- No detectable effect of P2 neurons on female post-mating changes in sleep and feeding inbioRxiv : the preprint server for biology · 2026Article
- Article
- A novel female reproductive organ differentiates insemination and postmating responses in bedbugs.Molecular biology and evolution · 2026Article
- Space-Dependent Oviposition Preference in Drosophila.Neuroscience bulletin · 2026Article
- Article
- Beyond the Black Box: Reproductive Strategies of the Black Soldier Fly as a Model for Bridging Evolutionary Biology and Applied Entomology.Evolutionary applications · 2026Review
- Disentangling the reproductive and metabolic transcriptional responses to diet in Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird.Molecular ecology · 2026Article
- A temperature-sensitive CRISPR-Cas12a system for sterile insect technique.Nature communications · 2025Article
- Article
- No Evidence of Sexually Antagonistic Coevolution in Drosophila Reproductive Tract Transcriptomes.Molecular biology and evolution · 2025Article
- Expression Divergence in Response to Sex-biased Selection.Molecular biology and evolution · 2025Article
- Two neuropeptide signaling pathways regulate post-mating refractoriness and reproductive system in male crickets.Communications biology · 2025Article
- Evidence for Transcriptomic Conservation Between the Main Cells of thebioRxiv : the preprint server for biology · 2025Article
- Monogamy removes constraints on reproductive tissue investment imposed by intense sexual selection.Scientific reports · 2025Article
- Two matings lead to more copulatory wounding than a single mating in femaleProceedings. Biological sciences · 2025Article
- A novel male accessory gland peptide reduces female post-mating receptivity in the brown planthopper.PLoS genetics · 2025Article
- Prior mating without fertilization increases subsequent litter size in mice.Biology letters · 2025Article
175 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
Mating induces profound changes in female insect behavior and physiology. In Drosophila melanogaster, mating causes a reduction in sexual receptivity and an elevation in egg production for at least 5 days. Injection of the seminal fluid sex peptide (SP) induces both responses in virgin females, but only for 1-2 days. The role of SP in eliciting the responses to mating remains to be elucidated. Functional redundancy between seminal fluid components may occur. In addition, mating with spermless males results in brief (1- to 2-day) post-mating responses, indicating either that there is a "sperm effect" or that sperm act as carriers for SP or other seminal fluid components. Here we used RNA interference to suppress SP expression, to determine whether SP is required to elicit full post-mating responses, the magnitude of responses due to other seminal fluid components, and whether SP accounts for the "sperm effect." Receptivity was higher and egg production lower in females mated to SP knock-down males than in controls. Comparison with virgins showed that the responses were brief. SP is therefore required for normal magnitude and persistence of postmating responses. Sperm transfer and use were normal in mates of SP knock-down males, yet their post-mating responses were briefer than after normal matings, and similar to those reported in mates of spermless son-of-tudor males. The prolonged "sperm effect" on female receptivity and egg production is therefore entirely attributable to SP, but sperm are necessary for its occurrence.
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