ArticleNucleic acids research2003
Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Systematic identification and characterization of repressive domains in Drosophila transcription factors.The EMBO journal · 2023Article
- The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target.Molecular cancer therapeutics · 2017Review
- A Looping-Based Model for Quenching Repression.PLoS computational biology · 2017Article
- Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator.Development (Cambridge, England) · 2016Article
- The effect of non-coding DNA variations on P53 and cMYC competitive inhibition at cis-overlapping motifs.Human molecular genetics · 2016Article
- Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family.Genes & development · 2015Article
- Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.The Journal of biological chemistry · 2014Article
- The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors.Genes & development · 2013Article
- Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.The Journal of biological chemistry · 2012Article
- Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein.G3 (Bethesda, Md.) · 2012Article
- Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.Molecular biology of the cell · 2010Article
- Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation.The EMBO journal · 2008Article
- Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.Development genes and evolution · 2007Article
- Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos.PLoS biology · 2007Article
- Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase.The Journal of biological chemistry · 2005Article
- cis-regulatory logic of short-range transcriptional repression in Drosophila melanogaster.Molecular and cellular biology · 2005Article
- Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1).Nucleic acids research · 2005Article
- CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner.Molecular and cellular biology · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Short-range transcriptional repressors are locally acting factors that play important roles in developmental gene expression in Drosophila. To effect repression, Knirps and other short-range repressors bind the CtBP corepressor, but these repressors also function via CtBP-independent pathways. Possible mechanistic differences between CtBP-dependent and -independent repression activities are poorly understood. The distinct activities might provide qualitatively different activities necessary in different promoter contexts, or they might combine to give quantitatively different effects. We analyze separately the CtBP-dependent and CtBP-independent domains of Knirps previously characterized in the embryo to determine possible functional distinctions of the two repression activities. Both domains are active in cell culture and are dependent on the same residues required for activity in the embryo. The domains have similar properties with respect to distance-dependent repression and resistance to inhibition by the deacetylase inhibitor trichostatin A. In tests of repressor-activator specificity, the extent of repression was related not to the chemical nature of the activation domain but to the total activation potential. This result indicates that the balance of competing activation and repression signals is decisive in determining the effectiveness of repressors on genetic switches, suggesting that multiple repression activities are utilized to provide quantitatively, rather than qualitatively, distinct outputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.