ArticleNucleic acids research2003
Transcription increases multiple spontaneous point mutations in Salmonella enterica.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Experimental evolution ofMicrobiology spectrum · 2025Article
- Mutation bias interacts with composition bias to influence adaptive evolution.PLoS computational biology · 2020Article
- Genetic Variants and Phenotypic Characteristics ofMicroorganisms · 2020Article
- Mutational Landscape of Spontaneous Base Substitutions and Small Indels in ExperimentalGenetics · 2019Article
- Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.PLoS biology · 2019Article
- Old Trade, New Tricks: Insights into the Spontaneous Mutation Process from the Partnering of Classical Mutation Accumulation Experiments with High-Throughput Genomic Approaches.Genome biology and evolution · 2019Review
- Spatial Vulnerabilities of theGenetics · 2018Article
- Transcription-associated mutagenesis.Annual review of genetics · 2014Review
- High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7.Mutation research · 2014Article
- On the mutational topology of the bacterial genome.G3 (Bethesda, Md.) · 2013Article
- High levels of transcription stimulate transversions at GC base pairs in yeast.Environmental and molecular mutagenesis · 2013Article
- Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Transcription as a source of genome instability.Nature reviews. Genetics · 2012Review
- Nucleotide and phylogenetic analyses of the Chlamydia trachomatis ompA gene indicates it is a hotspot for mutation.BMC research notes · 2012Article
- Signal correlations in ecological niches can shape the organization and evolution of bacterial gene regulatory networks.Advances in microbial physiology · 2012Review
- Changes in transcriptional orientation are associated with increases in evolutionary rates of enterobacterial genes.BMC bioinformatics · 2011Article
- Transcriptional de-repression and Mfd are mutagenic in stressed Bacillus subtilis cells.Journal of molecular microbiology and biotechnology · 2011Article
- Evidence that mutation is universally biased towards AT in bacteria.PLoS genetics · 2010Article
- Article
- Inferring clocks when lacking rocks: the variable rates of molecular evolution in bacteria.Biology direct · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The spontaneous rate of G.C-->A.T mutations and a hotspot T.A-->G.C transversion are known to increase with the frequency of transcription-increases that have been ascribed primarily to processes that affect only these specific mutations. To investigate how transcription induces other spontaneous point mutations, we tested for its effects in repair-proficient Salmonella enterica using reversion assays of chromosomally inserted alleles. Our results indicate that transcription increases rates of all tested point mutations in the induced gene: induction significantly increased the individual rates of an A.T-->T.A transversion, an A.T-->G.C transition and the pooled rates of the three other point mutations assayed. Although the S.enterica genome is thought to have a mutational bias towards G.C base pairs, transitions creating A.T pairs were approximately 10 times more frequent than the reverse mutation, resulting in an overall mutation pressure to lower G+C contents. Transitions occurred at roughly twice the rate of transversions, similar to results from sequence comparisons; however, several individual transversions are more frequent than the least common transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.