ReviewTrends in cell biology2003
Delivering the message: epimorphin and mammary epithelial morphogenesis.
Review in Trends in cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- The role of RHAMM in cancer: Exposing novel therapeutic vulnerabilities.Frontiers in oncology · 2022Review
- The role of S100A4 for bone metastasis in prostate cancer cells.BMC cancer · 2021Article
- Epimorphin regulates the intestinal stem cell niche via effects on the stromal microenvironment.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer.Journal of cancer research and clinical oncology · 2017Article
- Article
- Milk secretion: The role of SNARE proteins.Journal of mammary gland biology and neoplasia · 2014Review
- Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.PloS one · 2014Article
- Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Epimorphin is a novel regulator of the progesterone receptor isoform-a.Cancer research · 2013Article
- Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases.Cold Spring Harbor perspectives in biology · 2012Review
- Mammary gland reprogramming: metalloproteinases couple form with function.Cold Spring Harbor perspectives in biology · 2011Review
- FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer.Journal of mammary gland biology and neoplasia · 2010Review
- Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion.The Journal of clinical investigation · 2010Article
- Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.PloS one · 2010Article
- Changes in global gene expression during in vitro decidualization of rat endometrial stromal cells.Journal of cellular physiology · 2010Article
- Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.The Journal of biological chemistry · 2009Article
- Single proteins might have dual but related functions in intracellular and extracellular microenvironments.Nature reviews. Molecular cell biology · 2009Review
- A conserved role of the VEGF pathway in angiogenesis of an ectodermally-derived vasculature.Developmental biology · 2008Article
- The EGF repeat and discoidin domain protein, SED1/MFG-E8, is required for mammary gland branching morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation--polar versus apolar--epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.