Evidence map›Paper›PMID 12885985›Full record

ArticleThorax2003

Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS).

J W M Chan, C K Ng, Y H Chan, T Y W Mok, S Lee, S Y Y Chu, W L Law, M P Lee, P C K Li

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04513158 (Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2), which is not on this map. Cited by 217 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 13 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04513158 phase2terminatednot on this mapstarted 2020, after this paper: background citation

Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection

TypeinterventionalSponsorJoseph M. Flynn, D.O., MPHRan2020 to 2021Enrolled2ConditionsCovid19ArmsConvalescent Plasma
3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 13 syntheses or guidelines pooled it, 415 citations in OpenAlex.

  1. Pooled it
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  8. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Pooled it
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  10. Diabetes and COVID-19: A systematic review on the current evidences.Diabetes research and clinical practice · 2020
    Pooled it
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  12. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Pooled it
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  14. Trial
  15. ACE1 polymorphism and progression of SARS.Biochemical and biophysical research communications · 2004
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  17. Review
  18. Article
  19. Article
  20. Article

157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

J W M ChanDepartment of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, China. johnnychan@excite.com
C K Ng
Y H Chan
T Y W Mok
S Lee
S Y Y Chu
W L Law
M P Lee
P C K Li
Queen Elizabeth Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome (SARS) was diagnosed in Hong Kong in over 1700 patients between March and early June 2003.

methods115 patients diagnosed with SARS were admitted to Queen Elizabeth Hospital, a large regional hospital in Hong Kong, from March 2003, of whom 100 were either discharged or were dead at 31 May. The patients were prospectively studied after admission to assess their short term outcomes and the risk factors associated with adverse outcomes, defined as death or the need for mechanical ventilation

resultsAt the time of writing 18 patients had died, with a crude mortality rate of 15.7% and a 21 day mortality of 10% (standard error 3%). Thirty nine patients (34%) were admitted to the intensive care unit, 30 of whom (26%) required mechanical ventilation. Multivariate analysis showed that age above 60 (hazards ratio (HR) 3.5, 95% CI 1.2 to 10.2; p=0.02), presence of diabetes mellitus or heart disease (HR 9.1, 95% CI 2.8 to 29.1; p<0.001), and the presence of other comorbid conditions (HR 5.2, 95% CI 1.4 to 19.7; p=0.01) were independently associated with mortality. However, only the presence of diabetes mellitus and/or cardiac disease (HR 7.3, 95% CI 3.1 to 17.4; p<0.001) was associated with adverse outcomes as a whole.

conclusionSARS is a new disease entity that carries significant morbidity and mortality. Specific clinical and laboratory parameters predicting unfavourable outcomes have been identified.

Indexed as

AdultAgedFemaleHong KongHumansMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsReverse Transcriptase Polymerase Chain ReactionRisk FactorsSevere Acute Respiratory SyndromeSurvival AnalysisSurvival Rate

Identifiers

PMID12885985
PMCPMC1746764
OpenAlexW1995666039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.