ArticleBiophysical journal2003
Comparison between the predictions of diffusion-reaction models and localized Ca2+ transients in amphibian skeletal muscle fibers.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
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- The sensitivity of fast muscle contractile function to the major components of the sarcomere Ca(2+)-cycling system.Biophysical chemistry · 2016Article
- Microdomain calcium fluctuations as a colored noise process.Frontiers in genetics · 2014Article
- Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers.The Journal of general physiology · 2012Review
- Functional expression of transgenic 1sDHPR channels in adult mammalian skeletal muscle fibres.The Journal of physiology · 2011Article
- Luminal Ca(2+) content regulates intracellular Ca(2+) release in subepicardial myocytes of intact beating mouse hearts: effect of exogenous buffers.American journal of physiology. Heart and circulatory physiology · 2010Article
- Dystrophic skeletal muscle fibers display alterations at the level of calcium microdomains.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Simulation of Ca2+ movements within the sarcomere of fast-twitch mouse fibers stimulated by action potentials.The Journal of general physiology · 2007Article
- Calcium release domains in mammalian skeletal muscle studied with two-photon imaging and spot detection techniques.The Journal of general physiology · 2006Article
- Propagation in the transverse tubular system and voltage dependence of calcium release in normal and mdx mouse muscle fibres.The Journal of physiology · 2005Article
- The action potential-evoked sarcoplasmic reticulum calcium release is impaired in mdx mouse muscle fibres.The Journal of physiology · 2004Article
- Comparison between the predictions of diffusion-reaction models and localized Ca2+ transients in amphibian skeletal muscle fibers.Biophysical journal · 2003Article
- Patching the membranes up - new views on cellular healing.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We developed a three-dimensional cylindrical diffusion-reaction model of a single amphibian myofibril in which Ca(2+) release occurred only at the Z-line. The model incorporated diffusion of Ca(2+), Mg(2+), and all relevant buffer species, as well as the kinetic binding reactions between the buffers and appropriate ions. Model data was blurred according to a Gaussian approximation of the point spread function of the microscope and directly compared with experimental data obtained using the confocal spot methodology. The flux parameters were adjusted until the simulated Z-line transient matched the experimental one. This model could not simultaneously predict key parameters of the experimental M- and Z-line transients, even when model parameters were adjusted to unreasonably extreme values. Even though the model was accurate in predicting the Z-line transient under conditions of high [EGTA], it predicted a significantly narrower Ca(2+) domain than observed experimentally. We modified the model to incorporate a broader band of release centered at the Z-line. This extended release model was superior both in simultaneously predicting critical features of the Z- and M-line transients as well as the domain profile under conditions of high [EGTA]. We conclude that a model of release occurring exclusively at the Z-line cannot explain our experimental data and suggest that Ca(2+) may be released from a broader region of the sarcoplasmic reticulum than just the T-tubule-sarcoplasmic reticulum junction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.