ArticleBiophysical journal2003
ATP-independent luminal oscillations and release of Ca2+ and H+ from mast cell secretory granules: implications for signal transduction.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Nicotine alters mucin rheological properties.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- The role of Ca2+ in the pathophysiology of pancreatitis.The Journal of physiology · 2014Review
- Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Inositol 1,4,5-trisphosphate receptor in chromaffin secretory granules and its relation to chromogranins.Cellular and molecular neurobiology · 2010Review
- Ca2+ dynamics in the secretory vesicles of neurosecretory PC12 and INS1 cells.Cellular and molecular neurobiology · 2010Article
- Article
- Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Review
- Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Eosinophil granules function extracellularly as receptor-mediated secretory organelles.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Review
- NAADP induces pH changes in the lumen of acidic Ca2+ stores.The Biochemical journal · 2007Article
- Mucin granule intraluminal organization.American journal of respiratory cell and molecular biology · 2007Review
- InsP3 signaling induces pulse-modulated Ca2+ signals in the nucleus of airway epithelial ciliated cells.Biophysical journal · 2005Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
InsP(3) is an important link in the intracellular information network. Previous observations show that activation of InsP(3)-receptor channels on the granular membrane can turn secretory granules into Ca(2+) oscillators that deliver periodic trains of Ca(2+) release to the cytosol (T. Nguyen, W. C. Chin, and P. Verdugo, 1998, Nature, 395:908-912; I. Quesada, W. C. Chin, J. Steed, P. Campos-Bedolla, and P. Verdugo, 2001, BIOPHYS: J. 80:2133-2139). Here we show that InsP(3) can also turn mast cell granules into proton oscillators. InsP(3)-induced intralumenal [H(+)] oscillations are ATP-independent, result from H(+)/K(+) exchange in the heparin matrix, and produce perigranular pH oscillations with the same frequency. These perigranular pH oscillations are in-phase with intralumenal [H(+)] but out-of-phase with the corresponding perigranular [Ca(2+)] oscillations. The low pH of the secretory compartment has critical implications in a broad range of intracellular processes. However, the association of proton release with InsP(3)-induced Ca(2+) signals, their similar periodic nature, and the sensitivity of important exocytic proteins to the joint action of Ca(2+) and pH strongly suggests that granules might encode a combined Ca(2+)/H(+) intracellular signal. A H(+)/Ca(2+) signal could significantly increase the specificity of the information sent by the granule by transmitting two frequency encoded messages targeted exclusively to proteins like calmodulin, annexins, or syncollin that are crucial for exocytosis and require specific combinations of [Ca(2+)] "and" pH for their action.
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