ReviewJournal of industrial microbiology & biotechnology2003
AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).
Review in Journal of industrial microbiology & biotechnology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Structural insights into transcription activation of theiScience · 2024Article
- Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces.PLoS biology · 2024Article
- The roles of SARP family regulators involved in secondary metabolism inFrontiers in microbiology · 2024Review
- Co-Expression of Transcriptional Regulators and Housekeeping Genes inMicroorganisms · 2023Article
- Influence of Low-Intensity Ultrasound onFoods (Basel, Switzerland) · 2022Article
- Phosphoproteome Dynamics of Streptomyces rimosus during Submerged Growth and Antibiotic Production.mSystems · 2022Article
- LuxR-Type SCO6993 Negatively Regulates Antibiotic Production at the Transcriptional Stage by Binding to Promoters of Pathway-Specific Regulatory Genes inJournal of microbiology and biotechnology · 2022Article
- MilR3, a unique SARP family pleiotropic regulator in Streptomyces bingchenggensis.Archives of microbiology · 2022Article
- Improved Production of ε-Poly-L-Lysine inFrontiers in microbiology · 2022Article
- System-Level Analysis of Transcriptional and Translational Regulatory Elements inFrontiers in bioengineering and biotechnology · 2022Article
- SCO6992, a Protein with β-Glucuronidase Activity, Complements a Mutation at theJournal of microbiology and biotechnology · 2021Article
- Functional investigation of AfsKRS regulatory system for pristinamycin biosynthesis in3 Biotech · 2021Article
- Regulatory Control of Rishirilide(s) Biosynthesis inMicroorganisms · 2021Article
- Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine BacteriumMarine drugs · 2021Article
- Modulation of Gene Expression in Actinobacteria by Translational Modification of Transcriptional Factors and Secondary Metabolite Biosynthetic Enzymes.Frontiers in microbiology · 2021Review
- Regulation of Protein Post-Translational Modifications on Metabolism of Actinomycetes.Biomolecules · 2020Review
- The Balance Metabolism Safety Net: Integration of Stress Signals by Interacting Transcriptional Factors inFrontiers in microbiology · 2019Review
- Regulation of specialised metabolites in Actinobacteria - expanding the paradigms.Environmental microbiology reports · 2018Review
- Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters.Microbial cell factories · 2018Article
- Biomass-derived molecules modulate the behavior of Streptomyces coelicolor for antibiotic production.3 Biotech · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The genome sequence of Streptomyces coelicolor A3(2) has revealed the presence of about 40 protein serine/threonine or tyrosine kinases. AfsK, which is able to phosphorylate AfsR, a transcriptional activator with ATPase activity, represents the first instance in which a bacterial Hanks-type protein kinase phosphorylates a specific protein and exerts biologically important functions. The AfsK-AfsR system in S. coelicolor A3(2) globally controls secondary metabolism. The signal transduction pathway so far demonstrated or suggested is as follows: AfsK loosely attached to the membrane autophosphorylates threonine and serine residues, perhaps on sensing some external stimulus, and enhances its kinase activity. The kinase activity is modulated by KbpA, an AfsK-binding protein, by means of protein-protein interactions. The activated AfsK phosphorylates threonine and serine residues of AfsR in the cytoplasm, by which the DNA-binding activity of AfsR is greatly enhanced. In addition to AfsK, other kinases-including PkaG and AfsL-also phosphorylate AfsR, suggesting that AfsR serves as an integrator of multiple signals sensed by these kinases. The phosphorylated AfsR binds the promoter of afsS, which encodes a protein of 63 amino acids, and forms a closed complex with RNA polymerase. The closed complex is then converted to a transcriptionally active open complex by the energy available from ATP hydrolysis by AfsR. AfsS induced in this way activates transcription of pathway-specific transcriptional activators, such as actII-ORF4 for actinorhodin production and redD for undecylprodigiosin, in an as yet unknown manner.
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Registered trials
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