ArticleParasitology research2003
Selenium supplementation at low doses contributes to the decrease in heart damage in experimental Trypanosoma cruzi infection.
Article in Parasitology research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial.Trials · 2014Trial
- Evaluation of the prophylactic and therapeutic effects of selenium and vitamin E on the muscular phase of experimentalJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Selenium, TGF-Beta and Infectious Endemic Cardiopathy: Lessons from Benchwork to Clinical Application in Chagas Disease.Biomolecules · 2022Review
- Selenium and selenoproteins in prostanoid metabolism and immunity.Critical reviews in biochemistry and molecular biology · 2019Review
- Experimental and Clinical Treatment of Chagas Disease: A Review.The American journal of tropical medicine and hygiene · 2017Review
- Leishmanicidal activities of novel methylseleno-imidocarbamates.Antimicrobial agents and chemotherapy · 2015Article
- Review
- Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries.World journal of cardiology · 2012Article
- Would selenium supplementation aid in therapy for Chagas disease?Trends in parasitology · 2011Article
- Nutritional Status Driving Infection by Trypanosoma cruzi: Lessons from Experimental Animals.Journal of tropical medicine · 2011Article
- Antileishmanial activity of imidothiocarbamates and imidoselenocarbamates.Parasitology research · 2011Article
- The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection.Parasitology research · 2010Article
- Selenium supplementation at low doses contributes to the antioxidant status in Trichinella spiralis-infected rats.Parasitology research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chagasic patients with cardiomyopathy have low levels of selenium (Se), a fundamental trace element. We evaluated the effect of supplementing infected mice with Se (0.25-16 ppm). Supplementation with 0.25 or 1 ppm Se led to parasitaemia and survival curves similar to those of the control group. Mice treated with 4-16 ppm showed a dose-dependent decrease of parasitaemia, significant for the highest concentration. This was probably due to a direct effect on the parasites, which were lysed after in vitro incubation with Se. Survival rates did not change significantly; however, heart damage was reduced in infected mice supplemented with 4 ppm Se, as indicated by a lower cardiac isoform of creatine kinase levels. Our results imply that Se supplementation does not lead to a general protection during infection, but may help protect the heart from inflammatory damage. The effect of Se supplementation in the course of T. cruzi infection depends on the host-parasite pair employed.
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