ArticleProceedings of the National Academy of Sciences of the United States of America2003
Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03325517 (Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.Nature communications · 2022Article
- Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells.Theranostics · 2021Article
- Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma.Cancer research · 2016Article
- Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics.Journal of virology · 2013Article
- p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.The Journal of investigative dermatology · 2013Article
- Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells.PloS one · 2013Article
- Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.Journal of virology · 2009Article
- The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter.Journal of cell science · 2009Article
- c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells.The Journal of biological chemistry · 2009Article
- Adenovirus transforming protein E1A induces c-Myc in quiescent cells by a novel mechanism.Journal of virology · 2009Article
- p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc.Oncogene · 2008Article
- Simian virus 40 large T overcomes p300 repression of c-Myc.Virology · 2008Article
- Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.Oncogene · 2007Article
- Article
- Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.Molecular biology of the cell · 2006Article
- Transcriptional analysis of avian embryonic tissues following infection with avian infectious bronchitis virus.Virus research · 2005Article
- Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression.Oncogene · 2005Article
- An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry.Molecular and cellular biology · 2004Article
- HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy.The Journal of clinical investigation · 2003Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
p300 and cAMP response element binding protein (CREB)-binding protein (CBP) are two highly homologous, conserved transcriptional coactivators, and histone acetyltransferases (HATs) that link chromatin remodeling with transcription. Cell transformation by viral oncogene products such as adenovirus E1A and SV40 large T antigen depends on their ability to inactivate p300 and CBP. To investigate the role of p300 in cell-cycle progression, we constructed stable rat cell lines, which conditionally overexpress p300 from a tetracycline-responsive promoter. When p300 was induced in these cells, serum-stimulated S-phase entry was significantly inhibited. The inhibition of S-phase induction was associated with down-regulation of c-Myc, but not of c-Fos or c-Jun. Simultaneous overexpression of c-Myc and p300 before serum stimulation reversed the inhibition of S-phase induction to a significant level, indicating that the inhibition of c-Myc to a large extent is responsible for the p300 inhibition of G1 exit. Similar studies with stable rat cell lines that overexpress a mutant p300, which lacks the HAT activity, showed that the intrinsic HAT activity of p300 is not required for the negative regulation of c-Myc or G1. These findings, and our previously published results (Kolli, S., Buchmann, A. M., Williams, J., Weitzman, S. & Thimmapaya, B. (2001) Proc. Natl. Acad. Sci. USA 98, 4646-4651), establish an important negative regulatory role for p300 in c-Myc expression that may be important in maintaining the cells in the G0/G1 phase of the cell cycle.
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