ArticleProceedings of the National Academy of Sciences of the United States of America2003
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age.Research square · 2026Article
- TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.Nucleic acids research · 2023Article
- TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.bioRxiv : the preprint server for biology · 2023Article
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- Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans.Disease models & mechanisms · 2022Article
- Transcription Factors That Control Behavior-Lessons FromFrontiers in neuroscience · 2021Review
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- Glial development and function in the nervous system of Caenorhabditis elegans.Cold Spring Harbor perspectives in biology · 2015Review
- Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Investigating the Relationship between Topology and Evolution in a Dynamic Nematode Odor Genetic Network.International journal of evolutionary biology · 2012Article
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- The glia of Caenorhabditis elegans.Glia · 2011Review
- Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Generation and modulation of chemosensory behaviors in C. elegans.Pflugers Archiv : European journal of physiology · 2007Review
- Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system.Genome biology · 2007Article
- Expression of AmphiPOU-IV in the developing neural tube and epidermal sensory neural precursors in amphioxus supports a conserved role of class IV POU genes in the sensory cells development.Development genes and evolution · 2006Article
- Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activity of transcription factors modulates several neural pathways that mediate complex behaviors. We describe here the role of the POU transcription factor UNC-86 in the olfactory behavior of Caenorhabditis elegans. unc-86-null mutants are defective in response to odor attractants but avoid odor repellents normally. Continuous UNC-86 activity is necessary for maintenance of odortaxis behavior; hyperactivation of UNC-86 by fusion to a VP16 activation domain dramatically enhances sensitivity to odor attractants and promotes odor-attractant adaptation. UNC-86 is not expressed in olfactory sensory neurons but is expressed throughout the life of the animal in the AIZ interneurons of the odorsensory pathway. We suggest that UNC-86 transcriptional activity regulates the expression of genes that mediate synaptic properties of AIZ and that hyperactive UNC-86::VP16 may enhance the expression of synaptic components to affect the capacity to analyze and process sensory information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.