ArticleOncogene2003
Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma.Hereditas · 2023Article
- Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer.Oncology reports · 2020Article
- High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining.Cancer cell international · 2020Article
- Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms.Journal of experimental & clinical cancer research : CR · 2019Article
- Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.Oncogene · 2015Article
- Establishment of the vertebrate kinetochores.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- The ABCs of CENPs.Chromosoma · 2011Review
- Apc mutation enhances PyMT-induced mammary tumorigenesis.PloS one · 2011Article
- Molecular characterization and association analysis of porcine PANE1 gene.Molecular biology reports · 2010Article
- Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.Genes & development · 2009Article
- Do 'basal-like' breast cancers really exist?Nature reviews. Cancer · 2009Review
- Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.Genes & development · 2008Review
- Glycolipid transfer proteins.Biochimica et biophysica acta · 2007Review
- Article
- Proteotypic classification of spontaneous and transgenic mammary neoplasms.Breast cancer research : BCR · 2004Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
Beta-catenin is an executor of Wnt signaling and it can control cell fate and specification. Deletion of exon 3 from the endogenous beta-catenin gene in differentiating mammary alveolar epithelium of the mouse results in the generation of an activated protein that lacks amino acids 5-80. This is accompanied by a loss of mammary epithelial differentiation and a transdifferentiation process to squamous metaplasias. To further understand the molecular process of transdifferentiation, the expression of genes in mammary tissue was profiled in the absence and presence of activated of beta-catenin. Microarrays were generated that carry about 8500 cDNA clones with approximately 6000 obtained from mammary tissue. Mutant tissues, which had undergone either partial (TD1) or complete (TD2) squamous transdifferentiation, were compared with wild-type mammary tissue. Four groups of genes were identified. Group 1 contained genes whose expression was induced in both mutant tissues. Groups 2 and 3 contained genes that were active preferentially in TD2 and TD1, respectively. Group 4 contained genes suppressed in both samples. Using this approach, known and unknown genes activated in the transdifferentiation process were identified. A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells. Lastly, stabilization of beta-catenin resulted in the retention of differentiated epithelium upon involution and altered activities of several proteases in transdifferentiated mammary epithelium.
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