ArticleThe EMBO journal2003
Prokaryotic-style frameshifting in a plant translation system: conservation of an unusual single-tRNA slippage event.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Structural and Functional Insights into Viral Programmed Ribosomal Frameshifting.Annual review of virology · 2023Review
- Correction of frameshift mutations in the atpB gene by translational recoding in chloroplasts of Oenothera and tobacco.The Plant cell · 2021Article
- Thermodynamic control of -1 programmed ribosomal frameshifting.Nature communications · 2019Article
- Functional and structural characterization of the chikungunya virus translational recoding signals.The Journal of biological chemistry · 2018Article
- Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting.Nucleic acids research · 2018Article
- Translation in Prokaryotes.Cold Spring Harbor perspectives in biology · 2018Review
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Article
- Analysis of tetra- and hepta-nucleotides motifs promoting -1 ribosomal frameshifting in Escherichia coli.Nucleic acids research · 2014Article
- Transactivation of programmed ribosomal frameshifting by a viral protein.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Stem-loop structures can effectively substitute for an RNA pseudoknot in -1 ribosomal frameshifting.Nucleic acids research · 2011Article
- Virus versus host cell translation love and hate stories.Advances in virus research · 2009Review
- Ribosomal frameshifting in response to hypomodified tRNAs in Xenopus oocytes.Biochemical and biophysical research communications · 2008Article
- Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems.RNA (New York, N.Y.) · 2006Article
- Factors affecting translation at the programmed -1 ribosomal frameshifting site of Cocksfoot mottle virus RNA in vivo.Nucleic acids research · 2005Article
- A reassessment of the response of the bacterial ribosome to the frameshift stimulatory signal of the human immunodeficiency virus type 1.RNA (New York, N.Y.) · 2004Article
- A -1 ribosomal frameshift in the transcript that encodes the major head protein of bacteriophage A2 mediates biosynthesis of a second essential component of the capsid.Journal of bacteriology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ribosomal frameshifting signals are found in mobile genetic elements, viruses and cellular genes of prokaryotes and eukaryotes. Typically they comprise a slippery sequence, X XXY YYZ, where the frameshift occurs, and a stimulatory mRNA element. Here we studied the influence of host translational environment and the identity of slippery sequence-decoding tRNAs on the frameshift mechanism. By expressing candidate signals in Escherichia coli, and in wheatgerm extracts depleted of endogenous tRNAs and supplemented with prokaryotic or eukaryotic tRNA populations, we show that when decoding AAG in the ribosomal A-site, E.coli tRNA(Lys) promotes a highly unusual single-tRNA slippage event in both prokaryotic and eukaryotic ribosomes. This event does not appear to require slippage of the adjacent P-site tRNA, although its identity is influential. Conversely, asparaginyl-tRNA promoted a dual slippage event in either system. Thus, the tRNAs themselves are the main determinants in the selection of single- or dual-tRNA slippage mechanisms. We also show for the first time that prokaryotic tRNA(Asn) is not inherently 'unslippery' and induces efficient frameshifting when in the context of a eukaryotic translation system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.