ArticleThe EMBO journal2003
Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4.Theranostics · 2025Article
- Plant Adaptation and Tolerance to Heat Stress: Advance Approaches and Future Aspects.Combinatorial chemistry & high throughput screening · 2024Review
- Proteotoxic stress-induced autophagy is regulated by the NRF2 pathway via extracellular vesicles.Cell stress & chaperones · 2023Article
- Knockdown of heat shock transcription factor 1 decreases temperature stress tolerance in Bemisia tabaci MED.Scientific reports · 2022Article
- p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells.International journal of molecular sciences · 2022Article
- Exploring the ovine sperm transcriptome by RNAseq techniques. I Effect of seasonal conditions on transcripts abundance.PloS one · 2022Article
- Chemical rescue of mutant proteins in living Saccharomyces cerevisiae cells by naturally occurring small molecules.G3 (Bethesda, Md.) · 2021Article
- The dynamics and role of sphingolipids in eukaryotic organisms upon thermal adaptation.Progress in lipid research · 2020Review
- The AAA + ATPase valosin-containing protein (VCP)/p97/Cdc48 interaction network in Leishmania.Scientific reports · 2020Article
- Molecular chaperoning helps safeguarding mitochondrial integrity and motor functions in the Sahara silver ant Cataglyphis bombycina.Scientific reports · 2018Article
- Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease.Journal of neuroscience research · 2016Review
- Mathematical modeling of the heat-shock response in HeLa cells.Biophysical journal · 2015Article
- Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.Medical microbiology and immunology · 2014Article
- Article
- The innate immune system as mediator of systemic DNA damage responses.Communicative & integrative biology · 2013Article
- Overexpression of ubiquitin and amino acid permease genes in association with antimony resistance in Leishmania tropica field isolates.The Korean journal of parasitology · 2013Article
- Coordination of rapid sphingolipid responses to heat stress in yeast.PLoS computational biology · 2013Article
- Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.Virology journal · 2012Article
- Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells.Journal of lipid research · 2012Article
- Posttranslational modifications of proteins in the pathobiology of medically relevant fungi.Eukaryotic cell · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serine palmitoyltransferase, the first enzyme in ceramide biosynthesis, is required for resistance to heat shock. We show that increased heat shock sensitivity in the absence of serine palmitoyltransferase activity correlates with a lack of induction of the major heat shock proteins (Hsps) at high temperature. Normal heat shock resistance can be restored, without restoration of ceramide synthesis or induction of Hsps, by overexpression of ubiquitin. This function of ubiquitin requires the proteasome. These data imply that the essential function of Hsp induction is the removal of misfolded or aggregated proteins, not their refolding. This suggests that cells stressed by heat shock do not die because of the loss of protein activity due to their denaturation, but because of the inherent toxicity of the denatured and/or aggregated proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.