ReviewIUBMB life
Target selection and determination of function in structural genomics.
Review in IUBMB life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Use of a structural alphabet to find compatible folds for amino acid sequences.Protein science : a publication of the Protein Society · 2015Article
- Structural and functional studies of S-adenosyl-L-methionine binding proteins: a ligand-centric approach.BMC structural biology · 2013Article
- PSI:Biology-materials repository: a biologist's resource for protein expression plasmids.Journal of structural and functional genomics · 2011Article
- Structural genomics is the largest contributor of novel structural leverage.Journal of structural and functional genomics · 2009Article
- Structure-guided comparative analysis of proteins: principles, tools, and applications for predicting function.PLoS computational biology · 2008Article
- Small-scale, semi-automated purification of eukaryotic proteins for structure determination.Journal of structural and functional genomics · 2007Article
- Towards fully automated structure-based function prediction in structural genomics: a case study.Journal of molecular biology · 2007Article
- Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint.BMC bioinformatics · 2007Article
- ProTarget: automatic prediction of protein structure novelty.Nucleic acids research · 2005Article
- Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein.Structure (London, England : 1993) · 2005Article
- Conference report--structural genomics: parsing the architecture of proteins highlights of the ABRF 2004--integrating technologies in proteomics and genomics, February 28-March 2, 2004; Portland, Oregon.MedGenMed : Medscape general medicine · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
The first crucial step in any structural genomics project is the selection and prioritization of target proteins for structure determination. There may be a number of selection criteria to be satisfied, including that the proteins have novel folds, that they be representatives of large families for which no structure is known, and so on. The better the selection at this stage, the greater is the value of the structures obtained at the end of the experimental process. This value can be further enhanced once the protein structures have been solved if the functions of the given proteins can also be determined. Here we describe the methods used at either end of the experimental process: firstly, sensitive sequence comparison techniques for selecting a high-quality list of target proteins, and secondly the various computational methods that can be applied to the eventual 3D structures to determine the most likely biochemical function of the proteins in question.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.