ArticleOncogene2003
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 95 citations in OpenAlex.
- Predicting treatment outcome using kinome activity profiling in HER2+ breast cancer biopsies.iScience · 2024Article
- Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.The Journal of clinical investigation · 2021Article
- Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma.Frontiers in oncology · 2020Article
- The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome.BMC medical genetics · 2018Article
- Microtubule Motors in Establishment of Epithelial Cell Polarity.Cold Spring Harbor perspectives in biology · 2018Review
- Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.The Journal of clinical investigation · 2017Article
- Celiac Disease: Role of the Epithelial Barrier.Cellular and molecular gastroenterology and hepatology · 2017Review
- Micellar nanocomplexes for biomagnetic delivery of intracellular proteins to dictate axon formation during neuronal development.Biomaterials · 2017Article
- Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice.Frontiers of medicine · 2016Article
- Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Review
- LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.Molecular biology of the cell · 2016Article
- Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.Molecular and cellular biochemistry · 2015Article
- The tumor suppressor LKB1 antagonizes WNT signaling pathway through modulating GSK3β activity in cell growth of esophageal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.PloS one · 2012Article
- Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers.Cancer letters · 2011Review
- The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.Oncogene · 2011Review
- LKB1 gene alterations in surgically resectable adenocarcinoma of the lung.Surgery today · 2011Article
- Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.Molecular and cellular biology · 2010Article
- Immunohistological evidence for Wnt-signaling activation in Peutz-Jeghers polyposis.Pediatric surgery international · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss-of-function mutations in the LKB1 (STK11) serine-threonine kinase gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of LKB1 kinase activity have been identified. Here we show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A. The amino-acid residues phosphorylated as a result of LKB1 activity have been identified and phosphorylation at these residues is required for PAR1A kinase activity. PAR1A has previously been implicated as a positive regulator of the Wnt-betacatenin signalling pathway. We show here that LKB1 can modify transcription driven by the Wnt-regulated TCF response element, implicating LKB1 in a pathway known to play a key role in human colorectal tumorigenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.