ArticleOncogene2003
Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes.Theranostics · 2025Article
- The clinicopathological significance of BRI3BP in women with invasive breast cancer.Translational cancer research · 2024Article
- LETMD1 regulates mitochondrial protein synthesis and import to guard brown fat mitochondrial integrity and function.iScience · 2024Article
- Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.Nature communications · 2023Article
- HGF induces oncoprotein HCCR-1 expression through the Wnt/β-catenin pathway in gastric cancer.American journal of translational research · 2022Article
- LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei.BMC cancer · 2020Article
- Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients.Cancers · 2019Article
- Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review).Molecular medicine reports · 2019Review
- HCCR-1 is a Novel Prognostic Indicator for Gastric Cancer and Promotes Cell Proliferation.Journal of Cancer · 2019Article
- Discrimination of different cancer types clustering Raman spectra by a super paramagnetic stochastic network approach.PloS one · 2019Article
- A panel of autoantibodies against multiple tumor-associated antigens in the immunodiagnosis of esophageal squamous cell cancer.Cancer immunology, immunotherapy : CII · 2016Article
- Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3.Scientific reports · 2016Article
- Article
- The role of human cervical cancer oncogene in cancer progression.International journal of clinical and experimental medicine · 2015Review
- Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Human cervical cancer oncogene-1 over expression in colon cancer and its clinical significance.International journal of clinical and experimental medicine · 2015Article
- Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression.Oncology research · 2014Article
- Article
- Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basic studies of oncogenesis have demonstrated that either the elevated production of particular oncogene proteins or the occurrence of qualitative abnormalities in oncogenes can contribute to neoplastic cellular transformation. The purpose of this study was to identify unique oncogenes that are differentially expressed in human cancers and characterize their functions in tumorigenesis. To discover new putative oncogenes, the differential display RT-PCR method was applied using normal cervical tissues, cervical cancer cell lines, cervical cancer tissues, and metastatic tissues. We identified a new human cervical cancer oncogene HCCR-2 that was overexpressed in various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix. Ectopic expression of HCCR-2 resulted in direct tumorigenic conversions of NIH/3T3 and Rat1 fibroblasts. Nude mice injected with NIH/3T3 cells stably transfected with HCCR-2 formed tumors in 4 weeks. The resultant tumors display characteristics of an epithelial carcinoma. In HCCR-2 transfected NCI-H460 cells and RKO cells, stabilization of the p53 tumor suppressor occurred without genetic mutation and correlated with functional impairment, as indicated by the defective induction of p53-induced p21(WAF1), MDM2, and bax. These results indicate that HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.