ReviewHeart failure reviews2003
Cell cycle regulation to repair the infarcted myocardium.
Review in Heart failure reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cell-associated elastin fibers in porcine left ventricle.Bioactive materials · 2023Article
- Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs.Critical reviews in biomedical engineering · 2015Review
- Hyaluronic acid-based hydrogel induces neovascularization and improves cardiac function in a rat model of myocardial infarction.Interactive cardiovascular and thoracic surgery · 2013Article
- Harnessing the power of dividing cardiomyocytes.Global cardiology science & practice · 2013Review
- Prometheus's heart: what lies beneath.Journal of cellular and molecular medicine · 2012Article
- Myocyte proliferation in the developing heart.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Western array analysis of cell cycle protein changes during the hyperplastic to hypertrophic transition in heart development.Molecular and cellular biochemistry · 2007Article
- Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium.Circulation research · 2006Article
- Cardiac repair by embryonic stem-derived cells.Handbook of experimental pharmacology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower vertebrates such as newt and zebrafish are able to reactivate high levels of cardiomyocyte cell cycle activity in response to experimental injury resulting in apparent regeneration. In contrast, damaged myocardium is replaced by fibrotic scar tissue in higher vertebrates. This process compromises the contractile function of the surviving myocardium, ultimately leading to heart failure. Various strategies are being pursued to augment myocyte number in the diseased hearts. One approach entails the reactivation of cell cycle in surviving cardiomyocytes. Here, we provide a summary of methods to monitor cell cycle activity, and interventions demonstrating positive cell cycle effects in cardiomyocytes as well as discuss the potential utility of cell cycle regulation to augment myocyte number in diseased hearts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.