ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Dose-Dependent Effects of Myo-Inositol on Kainic Acid-Induced Epilepsy: Electrophysiological, Behavioral, Transcriptomic, and DNA Methylome Studies.International journal of molecular sciences · 2025Article
- Activation of Extrasynaptic Kainate Receptors Drives Hilar Mossy Cell Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1.Molecular neurobiology · 2019Article
- Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron.Frontiers in cellular neuroscience · 2015Review
- Optogenetic evocation of field inhibitory postsynaptic potentials in hippocampal slices: a simple and reliable approach for studying pharmacological effects on GABAA and GABAB receptor-mediated neurotransmission.Frontiers in cellular neuroscience · 2014Article
- Kainate receptor signaling in pain pathways.Molecular pharmacology · 2013Review
- A chemist and biologist talk to each other about caged neurotransmitters.Beilstein journal of organic chemistry · 2013Article
- Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors.The Journal of physiology · 2012Review
- Entorhinal theta-frequency input to the dentate gyrus trisynaptically evokes hippocampal CA1 LTP.Frontiers in neural circuits · 2012Article
- Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.PloS one · 2012Article
- Alzheimer's disease and metals: a review of the involvement of cellular membrane receptors in metallosignalling.International journal of Alzheimer's disease · 2011Article
- Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Article
- Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortex.Neuropharmacology · 2008Article
- Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy.Psychopharmacology · 2008Article
- Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Pre- and postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortex.Neuropharmacology · 2007Article
- Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex.Neuroscience · 2007Article
- Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.Neurobiology of disease · 2007Article
- Synaptic kainate currents reset interneuron firing phase.The Journal of physiology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of glutamate receptor subtypes on the surface of neurons is highly relevant for synaptic transmission and signal processing. In the present study we investigated the location and properties of functional kainate receptors (KARs) on the somatodendritic membrane of rat neocortical layer V pyramidal neurons. Infrared-guided laser stimulation was used to apply glutamate photolytically to the soma and various sites along the apical dendrite. Electrical currents, resulting from the activation of pharmacologically isolated KARs, were measured by whole-cell patch-clamp recording. In addition, KARs on somatic and dendritic outside-out patches were activated while still within the brain tissue. We found that functional KARs are located on the entire somatodendritic membrane that was examined. Fast kinetics, a linear I-V relationship, and a relatively high single-channel conductance are characteristic features of these receptors. We provide evidence that the unitary properties of somatic and dendritic KARs are identical. Regarding the subcellular distribution of KARs, our results indicate that the density of these receptors increases toward the distal dendrite. They are located mainly at extrasynaptic sites but also mediate fast synaptic signaling triggered by afferent stimulation. The differential distribution speaks in favor of a selective targeting of KARs on central neurons and may reflect a mechanism for a location-dependent regulation of synaptic efficacy. Furthermore, it is feasible to assume that extrasynaptic KARs could be activated by a "spillover" of synaptically released glutamate, ambient glutamate in the CSF, or glutamate released from adjacent astrocytes.
Indexed as
Identifiers
12878707PMC6740632W1858013900What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.