ArticleAntimicrobial agents and chemotherapy2003
Comparison of two methods and three end points in determination of in vitro activity of micafungin against Aspergillus spp.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Optimization of the EUCAST reference broth microdilution method for echinocandin susceptibility testing of Aspergillus fumigatus.The Journal of antimicrobial chemotherapy · 2023Article
- Comparison of Disc Diffusion, Etest, and a Modified CLSI Broth Microdilution Method forAntimicrobial agents and chemotherapy · 2021Article
- Development and multicentre validation of an agar-based screening method for echinocandin susceptibility testing of Aspergillus species.The Journal of antimicrobial chemotherapy · 2019Article
- Methods forJournal of pharmaceutical analysis · 2016Review
- In vitro antifungal activity of micafungin and caspofungin against dermatophytes isolated from China.Mycopathologia · 2013Article
- Review of the pharmacology and clinical studies of micafungin.Drug design, development and therapy · 2009Article
- Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds.Antimicrobial agents and chemotherapy · 2009Article
- Anidulafungin and its role in candida infections.Infection and drug resistance · 2009Article
- Micafungin in the treatment of invasive candidiasis and invasive aspergillosis.Infection and drug resistance · 2008Article
- Effect of caspofungin on metabolite profiles of Aspergillus species determined by nuclear magnetic resonance spectroscopy.Antimicrobial agents and chemotherapy · 2007Article
- Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.Antimicrobial agents and chemotherapy · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the in vitro activity of micafungin against clinical Aspergillus isolates (n = 37) (Aspergillusfumigatus [n = 21], Aspergillusflavus [n = 14], and Aspergillus niger [n = 2]) by using NCCLS M38A microdilution and an investigational disk diffusion assay. Microdilution assay results were evaluated by using the end points of a MIC-2 (measured in micrograms per milliliter) and minimum effective concentration (MEC, measured in micrograms per milliliter; the lowest concentration of micafungin that produces short and aberrant hyphal branchings microscopically). Disk diffusion results were interpreted by measuring the zone(s) of inhibition (ZOI, measured in millimeters). Micafungin proved to be similarly active against all Aspergillus species tested. At 24 h, MIC-2s and MECs were identical. At 48 h, however, MIC-2s increased unpredictably, leading to the loss of a consistent correlation between the two end points. MECs and ZOI remained consistent and correlated at both reading times, suggesting their use as relevant end points in susceptibility testing of micafungin against Aspergillus: All Aspergillus isolates yielded intrazonal growth on disk diffusion agar plates. The intrazonal colonies contained short, aberrant hyphal branchings microscopically. The in vivo significance of these findings remains to be further investigated.
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