Trial reportArchives of disease in childhood2003
Nebuliser hood compared to mask in wheezy infants: aerosol therapy without tears!
Trial report in Archives of disease in childhood, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 77 citations in OpenAlex.
- Hood versus mask nebulization in infants with evolving bronchopulmonary dysplasia in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2006Trial
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 1: Inflammatory Modulation and Respiratory Impacts.Children (Basel, Switzerland) · 2026Review
- Reconciling Oxygen and Aerosol Delivery with a Hood on In Vitro Infant and Paediatric Models.Pharmaceutics · 2021Article
- A path to successful patient outcomes through aerosol drug delivery to children: a narrative review.Annals of translational medicine · 2021Review
- Modified Small-Volume Jet Nebulizer Based on CFD Simulation and Its Clinical Outcomes in Small Asthmatic Children.Journal of healthcare engineering · 2019Article
- Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children.World journal of clinical pediatrics · 2016Review
- Maybe there is no such thing as bronchiolitis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Review
- Aerosol science and technology : the journal of the American Association for Aerosol Research · 2015Article
- Feasibility of aerosol drug delivery to sleeping infants: a prospective observational study.BMJ open · 2014Observational
- Aerosol delivery to ventilated newborn infants: historical challenges and new directions.European journal of pediatrics · 2011Review
- Guidelines for lung scintigraphy in children.European journal of nuclear medicine and molecular imaging · 2007Article
- Ethical aspects of using radiolabelling in aerosol research.Archives of disease in childhood · 2003Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall volume nebulisers (SVNs) with masks commonly provide aerosol therapy for infants with lung diseases. However, infants and toddlers are often disturbed by and thus reject masks.
aimsTo compare the lung deposition efficiency of the "usual" SVN aerosol mask and a prototype hood attached to an SVN. The advantage of the hood is that no mask is needed and medication can readily be administered during sleep.
methods99mTc salbutamol solution was administered at random by SVN plus mask or hood to 14 wheezy infants (mean age 8 (SD 5) months). The dose and distribution of salbutamol were evaluated using gamma scintigraphy. Clinical response, tolerability by the infants, and parent preference were also compared.
resultsMean total lung deposition was 2.6% with the hood and 2.4% with the mask (p > 0.05). Variability with the mask was greater than with the hood (coefficient of variation (CoV) 54% v 39%). Both treatments provided similar clinical benefit and side effects as reflected in improved oxygen saturation, reduced respiratory frequency, and increased heart rate. Infants accepted the hood better than the mask and there was a positive correlation between poor acceptance and upper airways and stomach deposition for both treatment modalities. Parents preferred the hood treatments.
conclusionsAerosol therapy by hood is as efficient as by mask but provides a better therapeutic index. It is much better tolerated by infants and preferred by parents. Hood nebulisation is a simple and patient friendly mode of aerosol therapy in wheezy infants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.