ArticleThe American journal of pathology2003
Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Integrated expression profiling reveals molecular crosstalk between CFTR, FASN, FRAP (mTOR), and BANK1 in hepatocellular carcinoma.Scientific reports · 2026Article
- HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-β/Smad signaling pathway.Histochemistry and cell biology · 2024Article
- Article
- Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC.Cancers · 2019Article
- Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity.European journal of histochemistry : EJH · 2018Article
- The biology of Hepatocellular carcinoma: implications for genomic and immune therapies.Molecular cancer · 2017Review
- Molecular profiling of liver tumors: classification and clinical translation for decision making.Seminars in liver disease · 2014Review
- Integration of genomic information in the clinical management of HCC.Best practice & research. Clinical gastroenterology · 2014Review
- Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma.International journal of cancer · 2014Article
- Application of microRNA and mRNA expression profiling on prognostic biomarker discovery for hepatocellular carcinoma.BMC genomics · 2014Article
- Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma.World journal of surgical oncology · 2013Article
- Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma.Nature reviews. Cancer · 2013Review
- Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis.PloS one · 2013Article
- Hepatocellular carcinoma: natural history, current management, and emerging tools.Biologics : targets & therapy · 2012Article
- A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.Functional & integrative genomics · 2011Article
- Molecular pathology of hepatic neoplasms: classification and clinical significance.Pathology research international · 2011Article
- Present and future possibilities for early diagnosis of hepatocellular carcinoma.World journal of gastroenterology · 2010Review
- Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy.Annual review of medicine · 2010Review
- Involvement of c-myc-regulated genes in hepatocellular carcinoma related to genotype-C hepatitis B virus.Journal of cancer research and clinical oncology · 2006Article
- Early liver cancer: concepts, diagnosis, and management.International journal of clinical oncology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to develop and validate a molecular index for the diagnosis of hepatocellular carcinoma (HCC) based on genes whose specificity and level of expression are the most discriminating for the diagnosis of HCC. The level of expression of 219 genes was assessed with a real-time reverse transcription-polymerase chain reaction approach in a training set of samples including normal livers (15), cirrhosis (12), and HCC (16). The most informative genes were selected for the molecular index. This index was prospectively validated in a new set of 40 samples (testing set) and in a set of 45 cirrhotic macronodules. 44 out of the 219 genes were differentially expressed in HCC. 13 out of these 44 genes were finally selected for the molecular index according to their diagnostic performance and after exclusion of most redundant genes. Using this index, 42 out of 43 samples of the training set and 39 out of the 40 samples of the testing set were correctly ranked as HCC or not HCC (normal liver or cirrhosis). The index also enabled correct ranking of 44 out of 45 cirrhotic macronodules into 2 groups: benign (including macroregenerative and dysplastic macronodules) and malignant macronodules. This molecular diagnostic index is an efficient tool both for identification of overt HCC as well as minute lesions (cirrhotic macronodules). It might be useful to correctly diagnose borderline lesion or small well-differentiated hepatocellular carcinomas whose diagnosis is often difficult on a histopathological basis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.