ArticleThe American journal of pathology2003
Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 96 citations in OpenAlex.
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- A Boolean network model of hypoxia, mechanosensing and TGF-β signaling captures the role of phenotypic plasticity and mutations in tumor metastasis.PLoS computational biology · 2025Article
- Ruthenium-Based Photoactivated Chemotherapy.Journal of the American Chemical Society · 2023Review
- Functional Imaging of Hypoxia: PET and MRI.Cancers · 2023Review
- NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment.Frontiers in pharmacology · 2023Review
- Pleotropic effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors: are they clinically relevant?Kidney research and clinical practice · 2023Article
- Hypoxia Enhances HIF1Stem cells international · 2022Article
- Article
- Ultrasound localization microscopy of renal tumor xenografts in chicken embryo is correlated to hypoxia.Scientific reports · 2020Article
- Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.PLoS pathogens · 2019Article
- Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.BMC cancer · 2018Article
- Active Role of the Necrotic Zone in Desensitization of Hypoxic Macrophages and Regulation of CSC-Fate: A hypothesis.Frontiers in oncology · 2018Article
- Hypoxia as a target for drug combination therapy of liver cancer.Anti-cancer drugs · 2017Article
- VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Anti-apoptotic response during anoxia and recovery in a freeze-tolerant wood frog (Rana sylvatica).PeerJ · 2016Article
- Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate.Cell death & disease · 2015Review
- Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats.Advanced pharmaceutical bulletin · 2015Article
- The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2.Oncogene · 2015Article
- Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans.Free radical biology & medicine · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hypoxia is an important pathogenic factor in ischemic disease and tumorigenesis. Under hypoxia, some cells are irreversibly damaged, whereas others adapt to the stress and may become more resistant to injury. The mechanism underlying such adaptive responses is unclear. Our recent study showed hypoxic induction of inhibitor of apoptosis protein-2 (IAP-2). Here we have investigated the critical steps in the apoptotic cascade that are affected by hypoxia and have identified a role for IAP-2 in apoptosis resistance of hypoxic cells. The results show that cells cultured in hypoxia became resistant to staurosporine-induced apoptosis. Apoptosis resistance of these cells took place at the mitochondria and in the cytosol. At the mitochondrial level, membrane accumulation of the proapoptotic molecule Bax was suppressed. This was accompanied by less cytochrome c (cyt. c) release from the organelles. In the cytosol, hypoxia induced IAP-2; the cytosol with IAP-2 was resistant to cyt. c-stimulated caspase activation. Of significance, immunodepletion of IAP-2 from the hypoxic cytosol restored its competence for caspase activation. Thus, death resistance of hypoxic cells involves multiple factors targeting different stages of apoptosis, with IAP-2 suppressing caspases in the cytosol.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.